In the present study, we examined the effects of antipsychotic drugs on histamine (HA) efflux in the mPFC of the rat by means ofin vivomicrodialysis and sought to differentiate the receptor mechanisms which underlie such effects. Olanzapine and clozapine increased mPFC HA efflux in a dose ...
In addition, typical antipsychotics also affectserotoninreceptors, which help improve mood and reduce negative symptoms, such as social withdrawal and lack of emotion. This dual action of dopamine and serotonin helps regulate neurotransmitter activity more broadly, which is believed to improve symptoms of...
Importantly, the finding that a very low dose of olanzapine reversed sensitization effects suggests that low-dose olanzapine may have clinical utility in a variety of disorders linked to sensitization of the dopamine system.Flávia Regina Cruz Dias...
Olanzapine and clozapine increased mPFC HA efflux in a dose related manner. Increased HA efflux was also observed after quetiapine, chlorpromazine, and perphenazine treatment. We found no effect of the selective 5-HT2A antagonist MDL100907, 5-HT2c antagonist SB242084, or the 5-HT6 antagonist Ro...
Unassociated with risk were sex, treatment response, length of hospital stay, drug potency, daily dose (in mg or mg/kg), drug exposure time, or cotreatments. CONCLUSIONS: EEG abnormality risk varied widely among specific antipsychotics. Risk was particularly high with clozapine and olanzapine, ...
D-serine efficacy as add-on pharmacotherapy to 2189 Neuropsychopharmacology 2190 Sex-dependent antipsychotic capacity of 17b-estradiol M Arad and I Weiner risperidone and olanzapine for treatment-refractory schizophre- nia. Biol Psychiatry 57: 577–585. Honack D, Loscher W (1993). Sex differences...
The clinical and neuropsychological performance of schizophrenic patients was assessed using the Brief Psychiatric Rating Scale (BPRS), the Positive And Negative... U Schneider,M Borsutzky,J Seifert,... - 《Schizophrenia Research》 被引量: 231发表: 2002年 Safety and effectiveness of olanzapine vers...
To do this, typical agents should be withdrawn slowly over a period of several weeks. Risperidone and olanzapine may be cautiously introduced during this withdrawal phase. Sertindole and clozapine should, in most circumstances, only be introduced once withdrawal of typical agents is complete. ...
Importantly, the finding that a very low dose of olanzapine reversed sensitization effects suggests that low-dose olanzapine may have clinical utility in a variety of disorders linked to sensitization of the dopamine system.doi:10.1007/s00213-013-3184-8Flávia Regina Cruz Dias...
like superoxide dismutase (SOD) and glutathione peroxidase (GPX) and the level of a lipid peroxidation maker (malondialdehyde-MDA), in schizophrenic patients treated with typical (haloperidol) or atypical (olanzapine, quetiapine and risperidone) antipsychotics, compared with age-matched healthy subjects....