The plasma concentrations of olanzapine after single doses are linear and dose-proportional within the approved dosage range (5 to 20mg) in healthy volunteers[39] and in patients with schizophrenia.[53] After administration of a single oral 12.5mg dose of olanzapine to 6 healthy volunteers, the ...
RLS symptoms emerged at olanzapine doses between 2.5 and 20mg. The symptoms improved in all patients when the dose was reduced and immediately disappeared when the medication was stopped. International Restless Legs Scale (IRLS) scores ranged from 10 to 35. Three patients had a family history of...
-mortem blood serum levels it is not uncommon that doses of olanzapine higher than recommended are prescribed to patients. Therapeutic serum levels of olanzapine are reported to be between 0.1–0.3 µM43,44; however, these serum levels are based on patients receiving only 5–20 mg/day. Inter...
The olanzapine monotherapy trial described above included a large cohort of Japanese patients and, to our knowledge, was the first double-blind, placebo-controlled trial to do so. Based on the results of this trial, Japan became the first country in the world to approve olanzapine monotherapy ...