RLS symptoms emerged at olanzapine doses between 2.5 and 20mg. The symptoms improved in all patients when the dose was reduced and immediately disappeared when the medication was stopped. International Restless Legs Scale (IRLS) scores ranged from 10 to 35. Three patients had a family history of...
-mortem blood serum levels it is not uncommon that doses of olanzapine higher than recommended are prescribed to patients. Therapeutic serum levels of olanzapine are reported to be between 0.1–0.3 µM43,44; however, these serum levels are based on patients receiving only 5–20 mg/day. Inter...
Since olanzapine clearly shows subtype selectivity for muscarinic receptors in vivo, the true equilibrium binding curves will not ex- actly follow the simple, single-component model em- ployed here; at higher doses of olanzapine where bind- ing to subtypes with low affinity becomes significant one...
The olanzapine monotherapy trial described above included a large cohort of Japanese patients and, to our knowledge, was the first double-blind, placebo-controlled trial to do so. Based on the results of this trial, Japan became the first country in the world to approve olanzapine monotherapy ...