Maximum dose: 10 mg IM 2 to 4 hours apart; additional doses in patients with clinically significant postural hypotension are not recommendedComments:The efficacy of repeated doses in agitated patients has not been systematically evaluated in controlled clinical trials. The safety of total daily dose...
(n= 21) found no significant change inQTc intervallength when switching from olanzapine to risperidone, suggesting similar risks with these two medications.108A case series of patients hospitalized for psychiatric reasons and receiving 40–160mg of olanzapine daily found that 1% of individuals ...
Olanzapine/fluoxetine (Symbyax®) is an oral once-daily fixed-dose combination of the atypical antipsychotic olanzapine and the selective serotonin reuptake inhibitor (SSRI) fluoxetine that is approved in the US for the treatment of depressive episodes associated with bipolar disorder in adults. Combin...
Effective dosage in clinical studies generally ranged from 2.5–20 mg daily (mean dosage of about 9 mg daily).Optimum duration of therapy not known, but maintenance therapy with olanzapine is well established in adults. In responsive patients, continue the drug beyond the acute response at the ...
Objective. To assess the potential risks associated with high-dose olanzapine treatment (> 40 mg daily) in inpatient psychiatric units. Methods. The study was an observational case series based on review of patient charts. The main inclusion criterion was treatment with at least one daily dose >...
Fluoxetine:Fluoxetine (60 mg single dose or 60 mg daily dose for 8 days) causes a small (mean 16%) increase in the maximum concentration of olanzapine and a small (mean 16%) decrease in olanzapine clearance. The magnitude of the impact of this factor is small in comparison to the overall...
However, pill return data was entirely missing for 9 participants and incomplete for several other participants, and so adherence to the intervention has instead been primarily defined in terms of daily doses prescribed (greater than 112 days). Consequently, this does not represent adherence to ...
887 (34) 0.6 596 (23) 612 (23) 1.5 a Data are presented as n (%) ASD absolute standardized difference, ADL activities of daily living An ASD ≤ 10% denotes a negligible difference between the two groups group was not significantly different to that in the olanzapine 5 mg group...
subsequent doses up to 10 mg may be given. However, the efficacy of repeated doses of intramuscular olanzapine for injection inagitated patients has not been systematically evaluated in controlled clinical trials. Also, the safety of total daily doses greater than 30 mg, or 10 mginjections give...
Male adolescent Sprague–Dawley rats (approximate postnatal days (∼P) 43–47) were first treated with OLZ (1.0 or 2.0 mg/kg, subcutaneously (sc)) or CLZ (10 or 20 mg/kg, sc) daily for 5 consecutive days in the CAR model. They were then tested for the expression of OLZ ...