Double-blind clinical trials that have examined doses of olanzapine greater than 20 mg/day are limited in number, but suggest that these doses may be helpful in selected patients who are treatment resistant, have high levels of psychopathology or who are acutely agitated. This must be balanced...
All patients were treated with oral olanzapine monotherapy. Titration was allowed for the first 2 weeks, and then the dose was kept constant throughout the remaining 6 weeks of treatment (mean dose 20 mg/day; SD ¼ 6.9 mg/day). Given the lack of reliable algorithms to handle mis- sing...
If this really was the source of clozapine’s special powers, it would be a really important big breakthrough. All through residency, I kept hearing “nobody really knows why clozapine is so great” or “it probably has something to do with its weak D2 binding affinity or something”. If...
The gray area displays plasma fluoxetine levels in humans taking 20–80 mg fluoxetine per day63,65. Full size image Discussion The results of the present study highlight that exposure to the SSRI FLX, in juvenile female mice, leads to a long-term anxiety-like behavioral profile in adulthood,...
The 5-HT2C antagonist activity of olanzapine, which could increase DA mesocorticolimbic function (Di Matteo et al., 2001), can be evoked accordingly to the monoamine deficiency hypothesis to explain this paradoxical result for a DA antagonist drug. Another explanation could be that an excessive DA...
Before the introduction of atypical antipsychotics (such as ziprasidone, clozapine, risperidone, olanzapine, and quetiapine), pimozide was frequently used as first-line therapy for DP. However, today, many psychiatrists would choose the newer antipsychotics over pimozide because of their better safety pr...
Activation of the JAK-STAT pathway is necessary for desensitization of 5-HT2A receptor-stimulated phospholipase C signalling by olanzapine, clozapine and MDL. Int. J. Neuropsychopharmacol. 2008, 12, 651–665. [Google Scholar] [CrossRef] Lejeune, D.; Dumoutier, L.; Constantinescu, S.; ...
Fluoxetine (Prozac).This SSRI was FDA-approved for MDD in people aged 8 and older, OCD in people aged 7 and older, panic disorder, bulimia nervosa, and added to olanzapine in people with treatment-resistant depression or depressive episodes in people with bipolar I disorder. It's one of th...
promazine, triflupromazine, levomepromazine, promethazine, chlorprothixene, flupenthixol, thiothixene, zuclopenthixol, haloperidol, droperidol, pimozide, melperone, benperidol, triperidol, clozapine, olanzapine, risperidone, quetiapine, ziprasidone, amisulpride, paliperidone, bifeprunox, aripiprazole....
Sections were imaged at 20× on an Olympus IX83 fluo- rescence microscope and stitched together using Olympus cellSens Dimension 2.3 software. Western blot. Adult mice were euthanized with 17.5 mg/ml Ketamine/2.5 mg/ml Xylazine at a dose of 0.1 ml per 20 g, then ...