The T-synthase(core 1 3-galactosyltransferase) is a glycosyl transferase responsible for converting GalNAcl-Ser/Thr(Tn antigen) to Gall.sGalNAc1- Ser/Thr(core 1 structure,T antigen),which is a precursor for many mucin type O-glycans on animal glycoproteins.Disruption of T-synthase in mice ...
The structures of O-glycans are often unusual or abnormal in cancer, and greatly contribute to the phenotype and biology of cancer cells. Some of the mechanisms of changes in O-glycosylation pathways have been determined in cancer model systems. However, O-glycan biosynthesis is a complex ...
O-LINKED GLYCAN BIOSYNTHESIS MODULATORS Provided herein are O-linked glycan inhibitors, including modulators of polypeptide GalNAc transferase, core transferase, polylactosamine-modifying glycosyl transferase, polylactosamine extension enzyme, core 1 specific chaperone, sialyl... CRAWFORD, Brett E.,BROWN, ...
Lowering the chase temperature to 15 degrees C completely inhibited the transfer of GalNAc to the peptide core indicating that O-glycan initiation takes place in the first Golgi elements and not in transitional vesicles between endoplasmic reticulum and Golgi. In addition, treatment of the cells ...
CD8 + T cells undergo an elimination of sialic acid on core 1 O-glycans and an i... JJ Priatel,D Chui,N Hiraoka,... - 《Immunity》 被引量: 554发表: 2000年 The ST3Gal-I Sialyltransferase Controls CD8+ T Lymphocyte Homeostasis by Modulating O-Glycan Biosynthesis T lymphocyte activation ...
TcR-alpha/beta(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. 机译:具有自身免疫性淋巴组织增生综合症的人类中的TcR-alpha / beta(+)CD4...
Autoimmune lymphoproliferative syndrome (ALPS), caused by inherited defects in apoptosis secondary to mutations in genes encoding Fas/CD95/APO-1 and Fas ligand (Fasl)/CD95L, is characterized by nonmalignant lymphadenopathy and splenomegaly, increased T cell receptor α/β+ CD4CD8 T cells (α/β...
When added to cultured leukocytes, breast cells, and prostate cells, Ac5GalNTGc increased cell-surface VVA binding by ~10-fold, indicating truncation of O-glycan biosynthesis. Cytometry, mass spectrometry, and western blot analysis of HL-60 promyelocytes demonstrated that 50–80 uM Ac5GalNTGc ...
肿瘤细胞O-GalNAc聚糖的生物合成途径 Pathways of O-GalNAc Glycan Biosynthesis in Cancer Cells. Chemistry of Life,2004,24 ( 4) : 350-353.周嘉梁 ,吴士 良.肿瘤细胞 O--GalNAc聚糖 的生 ... 周嘉梁,吴士良 - 《生命的化学》 被引量: 0发表: 2004年 Pathways of Mucin O-Glycosylation in Normal an...
Gal beta-R alpha 2-fucosyltransferase, synthesizing the blood group H determinant, were found to be 4-and 3-to 8-fold increased, respectively, in cancer compared to normal tissue, The data suggest that the biosynthesis of antigens and mucin-bound O-glycan structures in colon cancer is subject...