Mucin-type O-glycans, based on GalNAc 伪-linked to Ser/Thr in protein backbones, are widespread throughout the animal kingdom. Their unique properties allow mucins to form an essential protective barrier on epithelial tissues in mammals. The biosynthesis of all O-glycans is initiated by the ...
Mucin-type O-glycans, based on GalNAc α-linked to Ser/Thr in protein backbones, are widespread throughout the animal kingdom. Their unique properties allow mucins to form an essential protective barrier on epithelial tissues in mammals. The biosynthesis of all O-glycans is initiated by the tr...
typeO-glycansinmucusbarrierfunctionhasbeenuncertain.Recentstudiesutilizingmicedeficientinkeyglycosyltrans-ferasesinvolvedinO-glycanbiosynthesisonintestinalmucinshaveunderscoredtheimportanceofmucin-typeO-glycosylationinmucusbarrierfunction.Thisreviewwillhighlightrecentadvancesinourunderstandingofmucin-typeO-glycanfunctionin...
The sheep gut was specifically enriched in “N-glycan biosynthesis,”“mucin-type O-glycan biosynthesis,”“glycosaminoglycan biosynthesis-chondroitin sulfate,” and “lipopolysaccharide biosynthesis pathways.” However, “other glycan degradation pathways,”“glycosaminoglycan degradation pathways,” and “...
Here, overviews of the present knowledge of invertebrate mucin-type O-glycan structures and the currently identified enzymes responsible for the biosynthesis of these oligosaccharides are presented, and the few data dealing with functional aspects of O-glycans are summarised. 展开 关键词: O-...
Crystal structural analysis suggests that the polyproline type II structure that is dispersed throughout the tandem repeats imparts a stiffening of the backbone to keep MUC7 in a semi-rigid rod shape like a “bottle-brush” model. View article Mucins: Structural diversity, biosynthesis, its role...
(i.e., a single type of glycan) or on fluctuating dietary input from the host. The HMO-consuming community can utilize structurally similar mucins; we show here that bacteria prevalent in healthy humans possess a diverse array of GHs capable of mucin glycan degradation. The manner by which ...
I. Coordinate regulation of glycan degradation and polysaccharide capsule biosynthesis by a prominent human gut symbiont. J. Biol. Chem. 284, 18445–18457 (2009). Article CAS PubMed PubMed Central Google Scholar Falk, P., Hoskins, L. C. & Larson, G. Bacteria of the human intestinal ...
Interestingly, therapies specifically targeting mucin-linked O-glycosylation are now under active development, including a recently proposed hexosamine analogue that demonstrated potent inhibition of O-glycan biosynthesis and downregulation of neutrophil infiltration in rodents53. The prior- itisation of ...
Given that GalNAc-T3 seems to be ubiquitously expressed in human colon, one would envision that pathogenic bacterial enzymes of the type described here would not be able to degrade the MUC2 mucus layer under normal conditions and have gross effects. However, because O-glycosylation site occupancy ...