However, O-glycan biosynthesis is a complex process that is still poorly understood. The glycosyltransferases and sulfotransferases that synthesize O-glycans appear to exist as families of related enzymes of which individual members are expressed in a tissue- and growth-specific fashion. Studies of ...
Lowering the chase temperature to 15 degrees C completely inhibited the transfer of GalNAc to the peptide core indicating that O-glycan initiation takes place in the first Golgi elements and not in transitional vesicles between endoplasmic reticulum and Golgi. In addition, treatment of the cells ...
O-LINKED GLYCAN BIOSYNTHESIS MODULATORS Provided herein are O-linked glycan inhibitors, including modulators of polypeptide GalNAc transferase, core transferase, polylactosamine-modifying glycosyl transferase, polylactosamine extension enzyme, core 1 specific chaperone, sialyl... CRAWFORD, Brett E.,BROWN, ...
Human T-lymphocyte activation is associated with changes in O-glycan biosynthesis. J. Biol. Chem. 263, 15146-15150 T lymphocyte activation evokes distinct changes in cell surface O-glycans. CD8+ T cells undergo an elimination of sialic acid on core 1 O-glycans and an in... F Piller,V ...
Autoimmune lymphoproliferative syndrome (ALPS), caused by inherited defects in apoptosis secondary to mutations in genes encoding Fas/CD95/APO-1 and Fas ligand (Fasl)/CD95L, is characterized by nonmalignant lymphadenopathy and splenomegaly, increased T cell receptor α/β+ CD4CD8 T cells (α/β...
TcR-alpha/beta(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. 机译:具有自身免疫性淋巴组织增生综合症的人类中的TcR-alpha / beta(+)CD4...
Gene Namephosphatidylinositol glycan anchor biosynthesis class O Gene SymbolPIGO SynonymsHPMRS2 OrganismHuman Gene ID84720 UniProt IDQ8TEQ8 Main Accession No.NM_032634 Other Accession No.NM_001201484, NM_032634, NM_152850, NM_152850.1, NM_152850.2, NM_152850.3, NM_032634.1, NM_032634.2, NM_0326...
摘要黏蛋白是细胞表面的或分泌的、具有高度O-糖基化修饰的糖蛋白,在黏蛋白中,O-聚糖(O-glycan)是通过N-乙酰氨基半乳糖与丝氨酸或苏氨酸之间形成琢连接,该结构即被称为黏蛋白型O-聚糖,黏蛋白型O-聚糖是由多肽∶N-乙酰氨基半乳糖转移酶(ppGalNAc-T)家族催化起始合成的,近年来,该酶的催化机制及结构特点已成为...
Pathways of O-GalNAc Glycan Biosynthesis in Cancer Cells. Chemistry of Life,2004,24 ( 4) : 350-353.周嘉梁 ,吴士 良.肿瘤细胞 O--GalNAc聚糖 的生 ... 周嘉梁,吴士良 - 《生命的化学》 被引量: 36发表: 2004年 肿瘤细胞O-GalNAc聚糖的生物合成途径 Pathways of O-GalNAc Glycan Biosynthesis in ...
Gal beta-R alpha 2-fucosyltransferase, synthesizing the blood group H determinant, were found to be 4-and 3-to 8-fold increased, respectively, in cancer compared to normal tissue, The data suggest that the biosynthesis of antigens and mucin-bound O-glycan structures in colon cancer is subject...