However, O-glycan biosynthesis is a complex process that is still poorly understood. The glycosyltransferases and sulfotransferases that synthesize O-glycans appear to exist as families of related enzymes of which individual members are expressed in a tissue- and growth-specific fashion. Studies of ...
Lowering the chase temperature to 15 degrees C completely inhibited the transfer of GalNAc to the peptide core indicating that O-glycan initiation takes place in the first Golgi elements and not in transitional vesicles between endoplasmic reticulum and Golgi. In addition, treatment of the cells ...
Biosynthesis of O-mannosyl glycan in mammals 萬谷 博 , 遠藤 玉夫 Protein, nucleic acid and enzyme 53(12), 1429-1433, 2008-09 萬谷,遠藤,玉夫 - 《Protein, Nucleic Acid\\&\\enzyme》 被引量: 5发表: 2008年 [Finding of O-mannosyl glycan in mammals and congenital muscular dystrophies due...
摘要黏蛋白是细胞表面的或分泌的、具有高度O-糖基化修饰的糖蛋白,在黏蛋白中,O-聚糖(O-glycan)是通过N-乙酰氨基半乳糖与丝氨酸或苏氨酸之间形成琢连接,该结构即被称为黏蛋白型O-聚糖,黏蛋白型O-聚糖是由多肽∶N-乙酰氨基半乳糖转移酶(ppGalNAc-T)家族催化起始合成的,近年来,该酶的催化机制及结构特点已成为...
Cosmc-A Unique Molecular Chaperone Regulating O-glycan Biosynthesis The mucin type O-glycans in human glycoprotein and mucins are important in many aspects of biologicalprocess,including in leukocyte trafficking.The biosynt... RD Cummings - 第八届全国复合糖生物化学与分子生物学学术会议 被引量: 0发表...
Pathways of O-GalNAc Glycan Biosynthesis in Cancer Cells. Chemistry of Life,2004,24 ( 4) : 350-353.周嘉梁 ,吴士 良.肿瘤细胞 O--GalNAc聚糖 的生 ... 周嘉梁,吴士良 - 《生命的化学》 被引量: 36发表: 2004年 肿瘤细胞O-GalNAc聚糖的生物合成途径 Pathways of O-GalNAc Glycan Biosynthesis in ...
Gal beta-R alpha 2-fucosyltransferase, synthesizing the blood group H determinant, were found to be 4-and 3-to 8-fold increased, respectively, in cancer compared to normal tissue, The data suggest that the biosynthesis of antigens and mucin-bound O-glycan structures in colon cancer is subject...
Glycan biosynthesisMuscular dystrophyα-dystroglycanopathyRibitol-5-phosphateBackground O-mannosyl glycans have been found in a limited number of glycoproteins ... H Manya,T Endo - Biochimica et Biophysica Acta (BBA) - General Subjects 被引量: 11发表: 2017年 O-Mannosyl Glycan and Muscular Dystroph...
The ST3Gal-I Sialyltransferase Controls CD8+ T Lymphocyte Homeostasis by Modulating O-Glycan Biosynthesis D. 2000. The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis. Immunity 12:273... John,J,Priatel,... - 《Immunity》 被引量: 509发表: ...