However, O-glycan biosynthesis is a complex process that is still poorly understood. The glycosyltransferases and sulfotransferases that synthesize O-glycans appear to exist as families of related enzymes of which individual members are expressed in a tissue- and growth-specific fashion. Studies of ...
A comparison between Jurkat and K562 cell glycosyltransferase involved in the biosynthesis of O-linked carbohydrates showed that a markedly lower activity of UDP-Gal:GalNAc alpha 1---Ser/Thr beta 1---3galactosyltransferase is apparently responsible for the presence of truncated O-glycans in the Jur...
生命的化学 2011年 31卷 6期 · 832 · CHEMISTRYOFLIFE2011,31(6) ●MiniReview 文章编 :1000—1336(2011)06-0832-06 O.聚糖的硫酸化与白细胞黏附及炎症 宋银宏 刘方玉 杨唐斌 三峡大学 学院,宜昌443002 湖北三峡职业技术学院 物化 』:学院,宜昌443000 摘要:0一聚糖(O—glycan)的硫酸化是指征硫转移酶...
TcR-alpha/beta(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. 机译:具有自身免疫性淋巴组织增生综合症的人类中的TcR-alpha / beta(+)CD4...
摘要黏蛋白是细胞表面的或分泌的、具有高度O-糖基化修饰的糖蛋白,在黏蛋白中,O-聚糖(O-glycan)是通过N-乙酰氨基半乳糖与丝氨酸或苏氨酸之间形成琢连接,该结构即被称为黏蛋白型O-聚糖,黏蛋白型O-聚糖是由多肽∶N-乙酰氨基半乳糖转移酶(ppGalNAc-T)家族催化起始合成的,近年来,该酶的催化机制及结构特点已成为...
O-糖基化修饰 在生物体的转录、翻译、核运输、细胞骨架的形成以及调节细胞器的功能中发挥着重要的作用。 通过影响细胞信号的传导, 在细胞吞噬、炎性细胞的迁移以及细胞内大分子物质的循环中也起着 重要作用。该文主要通过介绍蛋白分子O-糖基化修饰的基础理论以及O-糖基化修饰作用的几个方 面, 来简要阐述O-糖...
(phosphatidylinositol glycan anchor biosynthesis, class O) 基因基本信息 基因简称(symbol) PIGO [HGNC] [GeneCards] [NCBI] 基因种类(locus group) protein-coding gene 同源简称(alias symbol) DKFZp434M222|FLJ00135 基因家族代码(gene_family_id) 680 [HGNC] [GenScript] omim代码 614730 entrez码 ...
糖基化,这类从病毒到真核细胞都存在的翻译后修饰发挥着非常重要的生物学作用,但是这类模块化组装的聚合物由于不受基因编码的直接调控,无论是糖型鉴定还是糖基化修饰调控,都是非常棘手的【1】。探究糖基化修饰的蛋白底物,传统的方式...
of O-glycan biosynthesis, on the expression of MUC1 protein and sensitivity to an anti-MUC1 CTL line, designated TS, in gastric cancer JRST cells. ... Y Hinoda,T Takahashi,T Hayashi,... - 《Journal of Gastroenterology》 被引量: 38发表: 1998年 加载更多研究点推荐 O-glycan biosynthesis...
Gal beta-R alpha 2-fucosyltransferase, synthesizing the blood group H determinant, were found to be 4-and 3-to 8-fold increased, respectively, in cancer compared to normal tissue, The data suggest that the biosynthesis of antigens and mucin-bound O-glycan structures in colon cancer is subject...