6. Huang T, 2022, Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERα levels. 7. Ye Z, 2022, GALNT4 primes monocytes adhesion and transmigration by regulating O-Glycosylation of PSGL-1 in atherosclerosis. 8. Suzuki H,...
6. Huang T, 2022, Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERα levels. 7. Ye Z, 2022, GALNT4 primes monocytes adhesion and transmigration by regulating O-Glycosylation of PSGL-1 in atherosclerosis. 8. Suzuki H, 20...
6. Huang T,et al.2022, Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERα levels.Biochim Biophys Acta Gen Subj. 7. Ye Z,et al.2022, GALNT4 primes monocytes adhesion and transmigration by regulating O-Glycosylation of PSG...
(2014) Protein O- GalNAc Glycosylation - The Most Complex and Differentially Regulated PTM. Glycosciences: Biology and Medicine. Eds N. Taniguchi, in pressJoshi HJ, Steentoft C, Schjoldager KT, et al. Protein O-GalNAc glycosylation: the most complex and differentially regulated PTM. Glycosci ...
蛋白质糖基化(glycosylation)是生物体内最重要的蛋白质翻译后修饰(Post-translational modification,PTM)形式之一,可发生在细胞中50%-70%的蛋白质上[1]。糖基化修饰广泛参与了多种生理病理过程,与抗体药物、肿瘤生物标志物检测等临床应用密切相关[2]。蛋白质糖基化的主要形式为N-糖基化和O-糖基化,其中氧...
其中黏蛋白型O-糖基化修饰(Mucin-type O-glycosylation,也称为O-GalNAc糖基化修饰)在个体发育、肿瘤发生、细胞粘附等诸多生命活动中均发挥非常重要的作用,但是由于缺乏共有修饰序列信息和有效的O-糖基化分析技术手段,长期以来生物体有哪些蛋白会发生O-GalNAc糖基化修饰知之甚少,极大地限制了人们对蛋白质O-糖基化...
粘蛋白型O糖基化(O-GalNAc glycosylation)作为最重要的蛋白翻译后修饰种类之一,在诸如细胞粘附,信号传导和免疫应答等多种生命活动中都有参与1.异常的粘蛋白型O糖基化与肿瘤的生长和代谢有着紧密联系,所以对于异常的粘蛋白型O糖基化蛋白糖型的分析就很可能提高癌症临床诊断标志物筛选的特异性2-3.与N连接糖基化和...
该研究成果近日在国际知名期刊《ACS catalysis》在线发表:“Comprehensive Investigations of MUC1 O-glycosylation Process Reveal Initial Site Preference by the Polypeptide GalNAc Transferases”。 首先,研究团队成功解决了人源O-GalNAc糖...
基于生物质谱的蛋白质O-GalNAc糖基化修饰研究进展. 中国科学: 生命科学, 2018, 48: 113–123Zhao X Y, Shen B Q, Qin W J, et al. Advances in O-GalNAc glycosylation research based on biological mass spectrometry (in Chinese). Sci Sin Vitae,2018, 48: 113–123, doi: 10.1360/N052017-00137...
Protein glycosylation is one of the most common protein modifications. A major type of protein glycosylation is O-GalNAcylation, in which GalNAc-type glycans are attached to protein Ser or Thr residues via an O-linked glycosidic bond. O-GalNAcylation is