The review gives a survey of experimental nucleic acid structures containing one or more metal-mediated base pairs, including X-ray crystal structures as well as NMR solution structures. Starting with a selection of small-molecule structures involving model nucleobases, the overview is extended to ...
Why are nucleic acids important? In this lesson, understand the nucleic acid structure and function in the body. Find a few examples of the...
Many elegant examples have revealed the potential in integrating nucleic acid nanostructures in cells and in vivo where they can perform important physiological functions. In this Review, we summarize the current abilities of DNA/RNA nanotechnology to realize applications in live cells and then discuss...
5、The first tRNA detached from the its amino acids and he ribosome moves along the mRNAmolecule, and a new tRNA with the amino acids will bind with the next codon. 6、The polypeptide is formed gradually until the ribosome reach the stop codon, then the formation of thepolypeptideis complet...
Origami surfaces are also an advantageous platform for single-molecule analysis (Fig. 10e) [123], and the development of a DNA origami “frame” allowed for the investigation of various nucleic acid interactions [127]. At the same time, origami structures can be designed to mimic more ...
long-term stable and controllable gene expression or interference will be needed. Moreover, the safety of the nucleic-acid drugs is also critically important. Similar to small molecule and protein drugs, the toxicities and adverseside effectsof nucleicacid drugsmust be controlled within an acceptable...
by chemical theory and techniques.We have done some works related to function(DNAzyme, recognition),structures(G-quadruplex DNA,Z-DNA,RNA,Methyl DNA)and clinical application(DNA cross-links,telomerase inhibitors,miRNA detection, methyl DNA detection,SNP) of nucleic acid by small molecule regulation....
The axial rotational diffusion tensor coincides well with the overall shape of the molecule (Fig. S1b) and the determined structure fits well with the relaxation data. Together with the numerous interdomain NOE spectroscopy (NOESY) cross-signals (52), these data confirm tight interdomain ...
E. Peptide nucleic acid: a molecule with two identities. Acc. Chem. Res. 1999, 32, 624.Peptide nucleic acid. A molecule with two identities - Nielsen - 1998 () Citation Context ...s (PNAs) would be the most suitable for this purpose due to their unique features. PNAs are novel ...
& Fan, C. Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation. Nat. Chem. 9, 1056–1067 (2017). Article CAS PubMed Google Scholar Amir, Y. et al. Universal computing by DNA origami robots in a living animal. Nat. Nanotechnol. 9, 353–...