Describe the chemical structure of nucleic acids and how they relate to inheritance Explain the basic structure of nucleic acids. Give at least two major functions. Explain nucleic acids and gene expression by describing the structure of DNA and RNA, explaining DNA replication, and explaining the ...
Describe the chemical structure of nucleic acids and how they relate to inheritance Summarize how DNA and RNA differ in structure and function. Describe the structure of bacterial DNA. Examine three differences between DNA and RNA, then explain two main reasons, ...
Peptide nucleic acids (PNA) have recently been proposed as alternative reagents in experiments aimed to the control of gene expression. In PNAs, the pseudopeptide backbone is composed of N-(2-aminoethyl)glycine units and therefore is stable in human serum and cellular extracts. PNAs hybridize ...
We have recently described a novel intracellular pathway by which proteins and nucleic acids from endocytosed extracellular membrane vesicles (EVs) reach the nuclear compartment and alter the gene expression profile or cell fate34,35. Entry of endocytosed EVs into the nucleoplasmic reticulum (NR), ...
One reason for this lower accuracy of HLA-II epitope prediction is the dimer structure of the HLA-II making the peptide binding groove. In fact, the HLA-II ɑβ-chain combinations have been estimated to be over 4000 in number. In contrast, the combination of the HLA-I and β2-...
The human gut microbiome is highly personal. However, the contribution of gut physiology and environment to variations in the gut microbiome remains understudied. Here we performed an observational trial using multi-omics to profile microbiome compositio
of the Adaptation Module in Synechocystis” online in the internationally-renowned journal Nucleic Acids Research (IF: 11.501). The researchers proved the interactions among Cas1, Cas2 and Cas4 proteins through biochemical experiments, determined the crystal structure of Cas1-Cas2-Spacer ternary ...
This region may be the site for interactions with κ-carrageenan, phosphate, and other anions. In addition, most of the physiologically active peptides isolated from αS2-CN occur in this region. This structure should be viewed as a working model that can be changed as more precise ...
For example, within GATA6 and ARID1B, we suggest that pLoFs occurring in the first quarter of the CDS of the MANE Select transcript (corresponding to the first 146 and 583 amino acids of the proteins, respectively) do not cause disease and should not be routinely reported diagnostically. We...
Furthermore, the sample sizes in previous studies at CNV loci are often too small, and hence are inappropriate for population genetic structure analysis18,34,35. The large sample sizes in HapMap Phase III populations means that the probabilities of making either false-positive or negative CNV ...