This book reviews the structure-function relationship of nucleic acids, their role in the pathophysiology of the diseases, and as therapeutic targets for human diseases. The chapters discuss the role of nucleic acids in inflammatory diseases, neurodegenerative diseases, and cancer. The book also ...
OFNUCLEICACIDS AStructureforDeaxyribose NucleicAcid Background •posingoftheproblem 20世纪40年代末和50年代初,在DNA被确认为遗传 物质之后,人们不得不面临着一个难题:DNA必须能够携 带遗传信息,能够自我复制传递遗传信息,能够让遗传信 息得到表达以控制细胞活动,并且能够突变并保留突变。 这4点,缺一不可,应该...
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G-quadruplex G4 DNA secondary structure nucleic acids drug discovery Beyond the DNA Double Helix A chemist’s perspective on the function of a molecule, or a system of molecules, is typically led by a consideration of how molecular structure dictates function. The most widely recognised DNA struc...
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In principle, the folding of nucleic acids is controlled by the local base sequence in a precise and potentially predictable way; however, this knowledge alone cannot provide an understanding of the forces responsible for maintaining the distinct structures in nucleic acids. The overall physical ...
一个核苷酸的五碳糖3号碳原子和与另一个核苷酸的磷酸之间通过磷酸二酯键(phosphodiester bond)缩合,形成核酸的骨架(alternating sugar and phosphate molecules forming the ‘backbone’),骨架部分都是一样的,不同的是碱基的变化,最后形成的长链结构是就叫核酸(nucleic acids)或多核苷酸(polynucleotide)。
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Methods to control sequence-specific changes in nucleic acids have become powerful tools in molecular biology and hold promise for the therapeutic correction of disease-causing mutations [4, 137]. Targeting gene mutations or fine-tuning of protein function at the RNA level rather than the DNA level...
Deoxyribonucleic acid in eukaryotes wraps around the histone octamer to form nucleosomes1, the fundamental unit of chromatin. The N termini of histone H4 interact with nearby nucleosomes and play an important role in the formation of high-order chromatin structure and heterochromatin silencing2,3,...