Although the biological roles that nucleic acids fulfil are diverse, the structure and function of each molecule is elaborated from a common set of general properties. Keywords: DNA; RNA; double helix; hairpin; base pair; hydrogen bonddoi:10.1038/npg.els.0001335...
Structure-switching allosteric deoxyribozymes Allosteric DNA enzymes (aptazymes) are deoxyribozymes whose activity can be regulated by the binding state of an appended aptamer domain and have many ... JC Achenbach,R Nutiu,Y Li - 《Analytica Chimica Acta》 被引量: 117发表: 2004年 Identification...
Topics in Nucleic Acid Structure : Topics in Molecular and Structural Biology; volume 1 edited by S. Neidle General editors: W. Fuller and S. Neidle MacMil... D Shugar - 《Febs Letters》 被引量: 0发表: 1982年 A standard reference frame for the description of nucleic acid base-pair ...
The β-propeller and thigh domains in αV and the βI and hybrid domains in β8 are resolved in the structure (Fig. 2a, b). The co-crystallized peptide fragment of the TGF-β1 prodomain binds to the interface between the αV β-propeller and β8 βI domain. αVβ8 electron ...
Chemical Properties of Amino Acids and Protein Structure: There are multiple chemical properties and structures of amino acids that influence how their combinations lead to the structures of proteins. Answer and Explanation: Although one might think a...
These NAs differ in the structure of a pocket adjacent to the active site of the enzyme. Oseltamivir makes use of this pocket in binding to the NA and so resistance can occur with mutations. With N1, just a single mutation, H275Y, gives high-level resistance but the corresponding mutation...
The structure of 2',3'-didehydro-2',3'-dideoxynucleosides (d4Ns) was applied to design the novel bioisosteric 4'-seleno-d4Ns as potential inhibitors of human immunodeficiency virus reverse transcriptase (HIV RT). Conversion of 2',3'-dihy... YJ Ko,WJ Choi,JH Jun,... - 《Nucleic Acids...
Structure and mechanism in complex general acid-base catalyzed reactions The mechanisms of acid and base catalyzed carbonyl and acyl group reactions are determined largely by the lifetime of the initial addition intermeidate. Catalysis through diffusion-controlled trapping by relatively strong acids or ...
Structure of CedA bound to the open-promoter complex To gain further insight into the mechanism of CedA, we used cryo-EM to solve the structure of CedA bound to the RNAPσ70-open-promoter complex. Purified RNAPσ70 holoenzyme was first incubated with 85-bp DNA representing −60 to +25...
3.Structure of viruses Most viruses are too small to be seen under light microscope. All viruses consists of an RNA or DNA core genome surrounded by a protein coat capsid. The combined viral genome and capsid is called the nucleocapsid. The nucleic acid of a virus is surrounded by a ...