Although the biological roles that nucleic acids fulfil are diverse, the structure and function of each molecule is elaborated from a common set of general properties. Keywords: DNA; RNA; double helix; hairpin; base pair; hydrogen bonddoi:10.1038/npg.els.0001335...
The β-propeller and thigh domains in αV and the βI and hybrid domains in β8 are resolved in the structure (Fig. 2a, b). The co-crystallized peptide fragment of the TGF-β1 prodomain binds to the interface between the αV β-propeller and β8 βI domain. αVβ8 electron ...
Target detection by the naked eye: The action of an RNA‐cleaving allosteric DNAzyme in response to ligand binding was coupled to a rolling circle amplific... M. Monsur Ali,Yingfu Li - 《Angewandte Chemie International Edition》 被引量: 171发表: 2008年 Structure-switching allosteric deoxy...
OR gate has an opposite internal structure of AND gate. NOT gate has two switches, one for L input and one for H input. XOR contains four input-controlled switches. b–e, Signal transmission paths with all possible input combinations for AND (b), OR (c), NOT (d) and XOR (e) ...
These NAs differ in the structure of a pocket adjacent to the active site of the enzyme. Oseltamivir makes use of this pocket in binding to the NA and so resistance can occur with mutations. With N1, just a single mutation, H275Y, gives high-level resistance but the corresponding mutation...
The structure of 2',3'-didehydro-2',3'-dideoxynucleosides (d4Ns) was applied to design the novel bioisosteric 4'-seleno-d4Ns as potential inhibitors of human immunodeficiency virus reverse transcriptase (HIV RT). Conversion of 2',3'-dihy... YJ Ko,WJ Choi,JH Jun,... - 《Nucleic Acids...
3.Structure of viruses Most viruses are too small to be seen under light microscope. All viruses consists of an RNA or DNA core genome surrounded by a protein coat capsid. The combined viral genome and capsid is called the nucleocapsid. The nucleic acid of a virus is surrounded by a ...
The structure of telomeric DNA: DNA quadriplex formation The structure of telomeric DNA: DNA quadruplex formation. Nucleic Acids Res 1991; 1: 435-438.D. Sen and W. Gilbert, "The structure of telomeric DNA: DNA quadriplex formation," Current Opinion in Structural Biology, vol. 1, no... ...
Structure and mechanism in complex general acid-base catalyzed reactions The mechanisms of acid and base catalyzed carbonyl and acyl group reactions are determined largely by the lifetime of the initial addition intermeidate. Catalysis through diffusion-controlled trapping by relatively strong acids or ...
Nucleic Acids Res 41:2736–2745. https://doi.org/10.1093/nar/gks1321 Article CAS Google Scholar Langlois C, Mas C, Di Lello P, Jenkins LM, Legault P, Omichinski JG (2008) NMR structure of the complex between the Tfb1 subunit of TFIIH and the activation domain of VP16: structural ...