Nucleic acid binding protein 1 (or oligonucleotide/oligosaccharide-binding fold-containing protein 2A; NABP1) gene is located at chromosome 2q32.3 and comprises seven exons spanning 10.4 kb [115]. OB-binding fold domains are present in multiple proteins that play an essential role in DNA damage ...
(2009) Using dynamics-based comparisons to predict nucleic acid binding sites in proteins: an application to OB-fold domains. Bioinformatics, 25, 1876-1883.Zen,A. et al. (2009) Using dynamics-based comparisons to predict nucleic acid binding sites in proteins: an application to OB-fold ...
The protein component PhoRpp38 of Pyrococcus horikoshii ribonuclease P (RNase P) is known to be a multifunctional RNA-binding protein. Previous biochemical... JD Puglisi,JR Williamson - 《Current Opinion in Structural Biology》 被引量: 0发表: 2012年 Nucleic acid recognition by OB-fold proteins....
Sequence and structure-based alignments revealed a possible OB-fold single-strand nucleic acid-binding motif in Rpb7. Purified Rpb4-Rpb7 complex exhibited both single-strand DNA- and RNA-binding activities, and a small deletion in the putative OB-fold nucleic acid-binding surface of Rpb7 ...
Nucleic acid sensing in HSPC gene therapy DNA damage responses Restriction factors How to overcome cell intrinsic hurdles to gene engineering in HSPC Conclusions and perspectives References Acknowledgements Author information Ethics declarations Additional information Rights and permissions About this article This...
【NABP1】,别名::Nucleic Acid Binding Protein 1, OBFC2A, Sensor Of Single-Strand DNA Complex Subunit B2, Single-Stranded DNA-Binding Protein 2, SSB2, Oligonucleotide/Oligosaccharide-Binding Fold Containing 2A, Nucleic Acid-Binding Protein 1, Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protei...
[46]. Functionalization the surfaces of SNA with aptamer sequences as a nucleic acid shell is another improving mechanism for targeting and biodistribution of SNAs. In a study, Caroline D. et al. reported that functionalization protein(β-galactosidase)-SNA with DNA aptamers binding to transferrin...
First studies explored the requirements for nucleic acid binding by introducing the cationic amino acids lysine, arginines or ornithines [138,139], disulfide-forming nanoparticle-stabilizing cysteines [140,141], endosomal-buffering histidines [[141], [142], [143], [144], [145], [146], [147...
In reference to the nucleic molecules of the present invention, the binding free energy for a nucleic acid molecule with its complementary sequence is sufficient to allow the relevant function of the nucleic acid to proceed, e.g., RNAi activity. Determination of binding free energies for nucleic...
The small peak on the front shoulder of the 15-HETE is 15-keto-eicosatetraenoic acid. FIG. 2B shows chiral analysis of the methyl ester derivative of the 15-HETE product using a Chiralcel OB column with a solvent of hexane:isopropanol (100:2, v/v) and a flow rate of 1.1 ml/min. ...