Since the best template to model IFI16-HIN200 is Replication Protein A (RPA) in complex with single-stranded nucleic acids, we tested six RPA nucleic acid-binding characteristics for IFI16-HIN200. Our results indicate that IFI16-HIN200 is an RPA-like, OB-fold, nucleic acid-binding protein...
Nucleic acid and/or protein macromolecule based nanomedicines present an exciting avenue in medical care. Within the last three decades almost three-thousand gene therapy clinical trials have been performed, and at least nine gene therapy products reached medical market authorization, see [1] and http...
1). These observations suggest the presence of two different mechanisms of nucleic acid recognition depending on the vector genome structure and replication. RNA sensors Innate immune receptors detecting RNA are referred to as RIG-I like receptors (RLR). The three central members of the mammalian ...
Generally, the formation of these nanomedicines was firstly constructed the corporate drug pairs (CDP) (Figure 5A), which required certain interactions between small-molecular drug and nucleic acid, like as electrostatic adsorption, coordination bond or covalent coupling; then a biocompatible skeleton ...
Nucleic acid therapeutics open almost infinite possibilities. They can be designed to i) restore the normal biological functions of deficient proteins; ii) halt the production of abnormal deleterious protein while leaving all other proteins unaffected; iii) increase the synthesis of a protein of intere...
[46]. Functionalization the surfaces of SNA with aptamer sequences as a nucleic acid shell is another improving mechanism for targeting and biodistribution of SNAs. In a study, Caroline D. et al. reported that functionalization protein(β-galactosidase)-SNA with DNA aptamers binding to transferrin...
Particularly, the present invention also relates to novel methods of utilizing conjugates of synthetic binding units and nucleic acids to in active electronic array systems to produce novel array constructs from the conjugates, and the use of such constructs in various nucleic acid assay formats. In...
Functional HG67 transduces a G-protein coupled intracellular signal upon ligand binding. The identification of the amino acid and nucleic acid sequences of HG67 provide tools for obtaining functional receptors related to HG67 from other sources, for producing HG67 chimeric G-protein coupled receptors...
11. The nucleic acid expression cassette according to claim 10, wherein the therapeutic protein is a clotting factor. 12. The nucleic acid expression cassette according to claim 11, wherein the therapeutic protein is factor IX. 13. A vector comprising the nucleic acid regulatory element of claim...
A key aspect of this invention pertains to the discovery of a novel 15S-lipoxygenase (15-Lox-2) protein and nucleic acid encoding the 15-Lox-2 protein. Preferred nucleic acid and amino acid sequences for 15-Lox-2 are described in SEQ ID NO:1 and SEQ ID NO:2. It is another aspect...