Noun1. radioactive waste- useless radioactive materials that are left after some laboratory or commercial process is completed high-level radioactive waste- radioactive waste that left in a nuclear reactor after the nuclear fuel has been consumed ...
Another large protein–membrane assembly at the subcellular scale is thenuclear pore complex(NPC)[94•,95], located in the double bilayers of thenuclear envelopemediating particle exchange between nucleus and cytoplasm. Nsp1, anuclear poreprotein, is the major component of NPC.MDsimulations, perfo...
This arrangement creates a central channel ∼120 nm wide and ∼85 nm deep called the nuclear pore, which serves as a protein-dense passageway for transport of cargo between the nucleus and the cytoplasm (Figure 2A). Small molecules can freely diffuse through the pore but larger molecules (...
[Deguelin regulates cell cycle and nuclear pore complex protein Nup98 and Nup88 in U937 cells in vitro]. Deguelin regulates cell cycle and nuclear pore complex protein Nup98 and Nup88 in U937 cells in vitro]. Chen Yan,Liu Hong-Li,Cui Guo-Hui,Wu Qiu-... Y Chen,H Liu,G Cui,... -...
[53]. The C terminal FG domain is highly flexible and interacts with nuclear transport receptors, indicating its role in NCT [54]. Nup153 also binds to the nuclear lamina and Sun1 protein [61] of the LINC complex. Depletion of either Nup153 or lamin leads to NPC clustering, suggesting ...
The Nuclear Pore Complex (NPC) has emerged as an important hub for processing various types of DNA damage. Here, we uncover that fusing a DNA binding domain to the NPC basket protein Nup1 reduces telomere relocalization to nuclear pores early after telom
Mechanism of mRNA Transport Through the Nuclear Pore Nuclear export of mRNA is an essential process in eukaryotic gene expression. Immediately after initiation of transcription, mRNA binds to various proteins to form an mRNA–protein complex (messenger ribonucleoprotein: mRNP) [35,36]. The mRNA precu...
The facilitated transport pathways are initiated through the binding of soluble receptors to protein or ribonucleoprotein (RNP) cargo endowed with either nuclear localization sig...Doye, V., and Hurt, E. (1997). From nucleoporins to nuclear pore complexes. Curr. Opin. Cell Biol. 9, 401-411...
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et al. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p. EMBO J. 18, 4332–4347 (1999). CAS PubMed PubMed Central Google Scholar Stelter, P. et al. Molecular basis for ...