应用领域:免疫及造血系统研究,肿瘤或细胞移植等。 *使用本品系发表的文献需注明: M-NSG mice (Cat. NO. NM-NSG-001) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 表型分析 T、B、NK 细胞 FACS 检测 图1.M-NSG 小鼠脾脏中 T、B 和 NK 细胞缺失。取 BALB/c、NOD-scid 和 M...
Human, immune cells and/or human: tumor cells are administered to a genetically modified immunodeficient mouse according to aspects described herein and assays of one or more test substances can be performed using the provided mice.Michael A. Brehm...
Summarizing these findings, NSG mice are ideal hosts for in vivo engraftment studies. However, the complex immunodeficiency reduces tolerance to certain drugs, thus making those mice especially sensitive. Consequently, such dose finding and tolerance tests constitute a necessity for similar cancer ...
Research Application:免疫及造血系统研究,肿瘤或细胞移植等。 *Literature published using this strain should indicate: M-NSG mice (Cat. NO. NM-NSG-001) were purchased from Shanghai Model Organisms Center, Inc.. Validation Data 表型分析 T、B、NK 细胞 FACS 检测 图1.M-NSG 小鼠脾脏中 T、B 和 ...
Humanized immune reconstitution levels in huHSC-hIL3-hCSF2-Tg(M-NSG) mice 将新生的hIL3-hCSF2-Tg(M-NSG)小鼠进行亚致死计量辐照清髓,尾静脉注射脐血来源的CD34阳性的HSC细胞(1E5),并在注射后3-24周取血进行流式分析。 结果显示:huHSC-hIL3-hCSF2-Tg(M-NSG)小鼠呈现出良好的免疫重建效果,髓系细胞与...
RESEARCH ARTICLE NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice a11111 Madhavi Puchalapalli1¤a, Xianke Zeng1, Liang Mu1, Aubree Anderson1, Laura Hix Glickman2¤b, Ming Zhang2, Megan R. Sayyad3, Sierra Mosticone ...
*使用本品系发表的文献需注明: M-NSG mice (Cat. NO. NM-NSG-001) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 表型分析 T、B、NK 细胞 FACS 检测 图1.M-NSG 小鼠脾脏中 T、B 和 NK 细胞缺失。取 BALB/c、NOD-scid 和 M-NSG 小鼠的脾脏细胞,通过 FACS 对其中 T、B ...
Humanized PD-1 Mice Humanized PD-L1 Mice NMG Mice Other Models Rats Humanized Drug Targets Immunodeficient Diseases Reporters Cre-drivers Standard Strains Inbred Outbred Cells Reporter-labeled Primary Humanized Drug Targets Wild-type Others Supporting Solutions Colony Managemen...
In addition, a pattern of metastasis similar to that observed in human breast cancer patients (metastases to the lungs, liver, bones, brain, and lymph nodes) was found in NSG mice. Furthermore, there was an increase in the metastatic burden in NSG compared to nude mice that were injected ...
严重联合免疫缺陷小鼠 (Severe Combined Immunodeficient Mice) 1983年,Bosma(美国Fox Chase癌症研究所)在CB17近交系小鼠中发现位于16号染色体上的Prkdc基因存在隐性突变,并首次描述了缺乏功能性T和B淋巴细胞的严重联合免疫缺陷(SCID)小鼠。 SCID小鼠外观与普遍小鼠无差异,体重发育正常,但是胸腺和外周淋巴组织严重萎缩。