Analysis utilized Fisher's exact test, logistic regression, and Cox regression.Results:841 patients across 107 VA medical centers met search criteria. The median age was 73, and 95% were male. 21% were non-Hispanic black, 70% non-Hispanic white, and 2.5% Hispanic. 4% were never smokers....
The primary end point was PFS based on BICR via RECIST v1.1 criteria; secondary end points included OS, intracranial PFS (icPFS), intracranial duration of response (icDoR), intracranial overall response rate (icORR), time to treatment discontinuation (TTD), time to subsequent therapy (TTS...
The inclusion criteria required patients to have the follow- ing: (1) histologically proven oncogene-driven NSCLC; (2) stage IIIB, IIIC, or IV advanced NSCLC; and (3) to have undergone surgical resection as a form of local consolidative therapy after treatment with tyrosine kinase inhibitors (...
NSCLC免疫联合化疗一线治疗进展 胡洁 中山呼吸科 2018年8月10日 主要内容 免疫治疗的现状 -取得的成就 -面临的挑战 免疫联合化疗一线治疗进展 -可行性 -最新研究 免疫联合化疗一线治疗的思考 -安全性 -解决方案 2 免疫治疗的现状 • 取得的成就 • 面临的挑战 3 肿瘤免疫治疗发展与突破 •...
Results 457 pts met study criteria: 126 PEM-based and 331 NoICI. Median age was 76 years in both cohorts. PEM-based had more males (63% vs 51%; p = 0.02) Median months followed was 6 (PEM-based) and 4 (NoICI). For PEM-based , 23 (18%) had TPS 0, 36 (29%) had TPS 1...
Immunogenic cell death (ICD) is associated with adaptive stress response which promotes the maturation of dendritic cells (DCs). In a lung cancer mouse model, chemotherapy promotes the ICD pathway to enhance the anti-tumor ability of anti-PD-1 and anti-CTLA4 antibodies [84,85]. In addition,...