Immunogenic cell death (ICD)-inducers in non-small-cell lung carcinoma (NSCLC): current knowledge and future perspective. Clin Transl Oncol 25, 316–322 (2023). https://doi.org/10.1007/s12094-022-02949-x Download citation Received17 July 2022 Accepted05 September 2022 Published30 September ...
NSCLC diagnosis was determined through ICD9/10 codes. NGS tests ordered were limited to xT/xR (solid tumor DNA and RNA), xE (solid tumor whole exome), or xF (circulating tumor DNA). Aggregate unique patients with orders were summated on a per site basis. Descriptive statistics were used ...
10. Silvestri GA, Gonzalez AV, Jantz MA, et al. Methods for staging non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013;...
相较于奥希替尼,埃万妥单抗联合兰泽替尼的中位颅内无进展生存期(icPFS)展现出显著优势,3年icPFS率提高20%(38% vs 18%);联合疗法也展现出持续性的颅内病灶控制,3年颅内缓解持续时间(icDoR)率提高51%(51%对比0%)[3]。中位...
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GeoMETry mono-1研究队列4和队列5b(初治+经治)纳入13例基线有可测量颅内病灶的脑转移患者,基于BIRC评估的颅内ORR(icORR)达54%,颅内DCR(icDCR)达92.3%,且颅内应答迅速,全部应答患者在治疗开始后6周即有颅内缓解[6]。在中国注册临床研究Geo...
GeoMETry mono-1研究队列4和队列5b(初治+经治)纳入13例基线有可测量颅内病灶的脑转移患者,基于BIRC评估的颅内ORR(icORR)达54%,颅内DCR(icDCR)达92.3%,且颅内应答迅速,全部应答患者在治疗开始后6周即有颅内缓解[6]。在中国注册临床研究GeoM...
Immunogenic cell death (ICD) is associated with adaptive stress response which promotes the maturation of dendritic cells (DCs). In a lung cancer mouse model, chemotherapy promotes the ICD pathway to enhance the anti-tumor ability of anti-PD-1 and anti-CTLA4 antibodies [84,85]. In addition,...
2.2. Data Extraction and Handling Variables retrieved from the NCR included sex, age at diagnosis, morphology code (ICD-O 3rd edition), type of first-line treatment (categories including chemotherapy, radio- therapy, surgery, targeted therapy, other therapy, a combination of these, or no therapy...
Levels of extracellular L-Lactic acid were measured using the L-Lactic acid kit (Biosentec, Toulouse, France) according to manufacturer's guidelines. Both pH and L-Lactic acid levels were corrected for cell counts. 2.10. Metabolic Profiling Cells were seeded at an optimized cell density of 3 ...