TROPION-Lung05研究则进一步显示,Dato-DXd在伴有AGA的继往经治NSCLC患者中不仅展现出了令人鼓舞的整体疗效,且对患者颅内病灶同样具有一致的抗肿瘤活性,患者icORR、icDCR以及颅内临床获益率(icCBR)分别为22%、72%以及44%,icTTR与icDoR分别...
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Immunogenic cell death (ICD) is associated with adaptive stress response which promotes the maturation of dendritic cells (DCs). In a lung cancer mouse model, chemotherapy promotes the ICD pathway to enhance the anti-tumor ability of anti-PD-1 and anti-CTLA4 antibodies [84,85]. In addition,...
2.2. Data Extraction and Handling Variables retrieved from the NCR included sex, age at diagnosis, morphology code (ICD-O 3rd edition), type of first-line treatment (categories including chemotherapy, radio- therapy, surgery, targeted therapy, other therapy, a combination of these, or no therapy...