The mammalian cell is a eukaryotic cell characterized by the presence of a nucleus, and is the basic unit of human life in all its normal forms (e.g., brain, liver, and kidney) and its abnormal, differentiated forms (cancer). Advances in our understanding of the structure and origin of...
When MYB is overexpressed or inappropriately activated, some of these, and perhaps additional target genes, contribute to the transforming capacity of MYB. Therapeutic interventions that target MYB in malignancy have been limited, but the observation that ERα+ breast cancer cells have elevated MYB ...
Blockage of CRM1-dependent nuclear export of the adenovirus type 5 early region 1B 55-kDa protein augments oncogenic transformation of primary rat cells Oncogene is one of the world's leading cancer journals. It is published weekly and covers all aspects of the structure and function of ...
NORMAL AND CANCER STEM CELLS: DISCOVERY, DIAGNOSIS AND THERAPY INTERNATIONAL SCIENTIFIC CONFERENCE R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv October 5–6, ... E Board - 《Experimental Oncology》 被引量: 0发表: 2017...
and luminal progenitor cells can differentiate in culture to generate mature basal and luminal cell types, including ER+ cells that have been challenging to maintain in culture. Cells associated with increased cancer risk can also be propagated. Single-cell analyses of matched organoid cultures and...
Fig. 1: Overall structure. Full size image Fig. 2: Interactions of NSD2 with histones H3 and H2A and DNA. Full size image Interactions of NSD2 with histones and DNA Fig.2shows the interactions between NSD2 and histones in detail. Two arginine residues in the first α-helix of H3 (H3...
The mechanical features of individual cells have been regarded as unique indicators of their states, which could constantly change in accordance with cellular events and diseases. Particularly, cancer progression was characterized by the disruption and/or reorganization of actin filaments causing mechanical...
activity present in almost all cancer cells, but not in normal cells, and the validity of the assay was confirmed with secondary tumor-specific markers... Jay,F.,Dorsey,... - 《Cancer》 被引量: 64发表: 2014年 Methylation-Specific Oligonucleotide Microarray: A New Potential for High-Throughpu...
Environmental and genetic mutations can transform the cells in a co-operating healthy tissue into an ecosystem of individualistic tumour cells that compete... D Basanta,A Deutsch - Birkhäuser Boston 被引量: 53发表: 2008年 The ecology of cancer from an evolutionary game theory perspective The ...
The inability to distinguish cancer (CSCs) from normal stem cells (NSCs) has hindered attempts to identify safer, more effective therapies for hepatocellular carcinoma (HCC). The aim of this study was to document and compare cell membrane potential differences (PDs) of CSCs and NSCs derived from...