The discovery impacts on the research into cancerous cells. A cell needs to share chromosomes accurately when it divides otherwise the two new cells can end up with the wrong number of chromosomes. This is called aneuploidy and this has been linked to a range of tumours in different body org...
5d). The P2-orange clone formed monotonous sheets of cancer cells, exhibited weak immunoreactivity for pan-cytokeratin and often occupied sinusoidal structures. By contrast, P2-blue cells stained more strongly for pan-cytokeratin and, when clustered, surround densely packed lymphocyte cores (Fig. 5c...
We demonstrate the conservation of sponge and human DRG1 biological features, including intracellular localization and DRG1:DFRP1 binding, function of DRG1 in α-tubulin dynamics, and its role in cancer biology demonstrated by increased proliferation, migration and colonization in human cancer cells. ...
Protein expression was carried out in 1-liter cell cultures of Sf21 cells with plaque-purified viruses. To improve the yields of overexpressed protein, compound 1 was added to the culture at a final concentration of 10 μm at 24 h after infection. Cells were harvested 72 h after infection,...
demonstrated that a mouse embryonic blastocyst microenvironment could suppress the tumorigenic phenotype of teratocarcinoma cells, and the developmental plasticity of the tumor cells was manifested as they contributed to the formation of normal ... M Hendrix,E Seftor,R Seftor,... - 《Cancer Researc...
S100A4, a member of the S100 family of Ca2+-binding proteins, modulates the motility of both non-transformed and cancer cells by regulating the localization and stability of cellular protrusions. Biochemical studies have demonstrated that S100A4 binds to the C-terminal end of the myosin-IIA heav...
Finally, comparison of the TQS phospho-mutants with tethered TWIST1 overexpressing cells, T-T and T-E, suggested that TWIST1 TQS phosphorylation may be one factor resulting in T-E heterodimerization in prostate cancer cells. Materials and Methods Plasmids, Antibodies, and Reagents pBABE-TWIST1-...
The cytokine receptor family consists of a growing number of structurally and evolutionarily related transmembrane receptors. CRFB4 and IFNAR are two of th
7. Moreover, mRNA profiling of ovarian cancer biopsies revealed overexpression ofdsg2message in at least 50 samples analyzed (data not shown). It is thought that the epithelial phenotype of cancer cells and their ability to form physical barriers provides protection from the host immune system and...
Motile breast cancer cells were pre-seeded into the collagen matrix and when presented with a controlled chemical stimulation from the artificial vasculature, they migrated towards the vasculature structure. We believe this innovative vascular 3D ECM system can be used to provide novel insights into ...