网络释义 1. 非同义突变 ...同义突变(Synonymousmutation)、非同义突变(Nonsynonymous mutation)、无义突变(Nonsense mutation).Li等[1]的研究表明, …www.cnki.com.cn|基于1 个网页必应词典应用 准确权威无广告去官网了解更多 下载手机版必应词典 iOS Windows Phone Android 体验P C 版必应词典Win32 版Microsoft...
We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and...
(AIDS) in humans. Because the virus rapidly and constantly evolves, at the moment there is no cure nor vaccine against HIV infection. The HIV virus presents a very high mutation rate that allows it to evade the response of our immune system as well as the action of specific drugs. At ...
In order to further confirm the mutation at the Gh_D10G1253 was responsible for the increased tolerance to imazapic in cotton, the mutant allele of Gh_D10G1253 was transformed to Arabidopsis. The T1 and T2 generations of transgenic Arabidopsis were screened on 1/2 MS medium supplemented with...
Notably, virus clones with D67N mutation had higher viral production and caused more severe cytopathic effect (CPE) in human neural astrocytes U251 cells in vitro, indicating its potential neurological toxicity to human brain. These findings revealed that a single mutation D67N on ZIKV envelope...
Among these, the G912D mutation had the least effect on apoB-48 secretion as compared with A31P. These results indicate that the hypobetalipoproteinemia phenotypes of the five kindreds, such as the reduced plasma cholesterol, TAG, and apoB concentrations (Table 1), are not caused solely by...
Results showed that compared with the wild type of 378 Arg/Arg of BRAD1, the homozygotic type of 378 Ser/Ser with Arg378Ser site mutation had a protective effect (adjusted odds ratio: 0.628, 95% confidence interval: 0.306-1.145). Compared with individuals carrying the wild type of 24Pro/...
MutationAssessor, PROVEAN, VEST3, fathmm-MKL, MuPRO, iStable, PhD-SNP, and SNAP2. Sorting Intolerant from Tolerant or SIFT is an analysis program based on the PSI-Blast algorithm65that differentiates neutral and deleterious SNPs66and predicts deleterious effects by applying the sequence homology ap...
With this supervised learning approach, a given mutation is classified as disease or neutral35,36. MutPred is based on SIFT scores, the gain or loss of 14 different structural and functional properties. Two important scores are contained in the output of MutPred: a general score (g), and ...
A non-synonymous substitution is a nucleotide mutation that alters theamino acidsequence of a protein. When a non-synonymous substitution results in harmful biological change, the frequency of it can be low due to thenatural selection, usually <1%. On this occasion, a non-synonymous substituti...