Nonsynonymous mutations have a much greater effect on an individual than a synonymous mutation. In a nonsynonymous mutation, there is usually an insertion or deletion of a single nucleotide in the sequence during transcription when the messenger RNA is copying the DNA. This single missing or added ...
b A schematic diagram displaying the definition of uni-mutation SNPs. ref., reference. Mut., mutation. c the fractions of different types of mutations. d The annotations and proportions of genomic SNPs (left) and exonic SNPs (right) after the above filtering steps. The clip arts of human/...
the generation-time effect of mutation rate partially cancels the population-size effect of fixation probability. On the other hand, for DNA regions without genetic information, such cancellation is not predicted. The prediction was tested by comparing the patterns of synonymous andnonsynonymous substitut...
A non-synonymous substitution is a nucleotide mutation that alters theamino acidsequence of a protein. When a non-synonymous substitution results in harmful biological change, the frequency of it can be low due to thenatural selection, usually <1%. On this occasion, a non-synonymous substitut...
Keywords: variation interpretation; synonymous variation; mutation; terminology; variation naming; annotation Citation: Vihinen, M. When a Synonymous Variant Is Nonsynonymous. Genes 2022, 13, 1485. https://doi.org/10.3390/ genes13081485 Academic Editor: Christos K. Kontos Received: 8 August 2022 ...
variation interpretation; synonymous variation; mutation; terminology; variation naming; annotation1. Introduction Terminology in genetics is very important for precise transfer of information. Still, it is common to use confusing and even wrong terms, e.g., for variant types [1]. Variation Ontology...
variation interpretation; synonymous variation; mutation; terminology; variation naming; annotation1. Introduction Terminology in genetics is very important for precise transfer of information. Still, it is common to use confusing and even wrong terms, e.g., for variant types [1]. Variation Ontology...
variation interpretation; synonymous variation; mutation; terminology; variation naming; annotation1. Introduction Terminology in genetics is very important for precise transfer of information. Still, it is common to use confusing and even wrong terms, e.g., for variant types [1]. Variation Ontology...