Nonsynonymous mutations have a much greater effect on an individual than a synonymous mutation. In a nonsynonymous mutation, there is usually an insertion or deletion of a single nucleotide in the sequence during transcription when the messenger RNA is copying the DNA. This single missing or added ...
The Correlation Between Synonymous and Nonsynonymous Substitutions in Drosophila: Mutation, Selection or Relaxed Constraints? Genetics. 1998;150:767-75.Comeron, J. M., and M. Kreitman, 1998 The correlation between synonymous and nonsynonymous substitutions in Drosophila: Mutation, selection, or relaxed...
Assessing the Functional Characteristics of Synonymous and Nonsynonymous Mutation Candidates by Use of Large DNA Constructs A.M. Eeds, D. Mortlock, R. Wade-Martins, M.L. Summar The American Journal of Human Genetics Volume 80, Issue 4, Pages 740-750 (April 2007) DOI: 10.1086/513287 Copyright...
I examine the statistical properties of six methods of estimating numbers of synonymous and nonsynonymous substitutions. The six methods are Miyata and Yasunaga’s (MY) method; Nei and Gojobori’s (NG) method; Li, Wu and Luo’s (LWL) method...
the generation-time effect of mutation rate partially cancels the population-size effect of fixation probability. On the other hand, for DNA regions without genetic information, such cancellation is not predicted. The prediction was tested by comparing the patterns of synonymous andnonsynonymous substitut...
Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat. Protoc. 4, 1073–1081 (2009). 20 Schwarz, J. M., Cooper, D. N., Schuelke, M. & Seelow, D. MutationTaster2: mutation prediction for the deep-sequencing age. Nat. Methods 11, ...
We show that this WAS outperforms each individual method in the task of classifying missense SNVs as deleterious or neutral. Furthermore, we demonstrate that this WAS can be used not only for classification purposes (deleterious versus neutral mutation) but also as an indicator of the impact of...
Phylogenetic tree of the KTTs and nonsynonymous/synonymous mutation ratios (ω) comparison.ChunHua, YuanQuanYuan, HeKuan, PengJianBo, DiaoLiPing, JiangXing, TangSongPing, Liang
Human MutationLiu, X., Wu, C., Li, C., and Boerwinkle, E. (2016). dbNSFP v3.0: A one-stop database of functional predictions and annota- tions for human nonsynonymous and splice-site SNVs. Hum. Mutat. 37, 235-241.Liu, X., Wu, C., Li, C. and Boerwinkle, E. (2016) ...
Keywords: variation interpretation; synonymous variation; mutation; terminology; variation naming; annotation Citation: Vihinen, M. When a Synonymous Variant Is Nonsynonymous. Genes 2022, 13, 1485. https://doi.org/10.3390/ genes13081485 Academic Editor: Christos K. Kontos Received: 8 August 2022 ...