Nonsynonymous mutations have a much greater effect on an individual than a synonymous mutation. In a nonsynonymous mutation, there is usually an insertion or deletion of a single nucleotide in the sequence durin
Moreover, no wild-type sequence of Gh_D10G1253 was identified from these sequencing clones, indicating that the G-to-A mutation was homozygous in the Gh_D10G1253 gene of the Lu37-1 mutant (i.e., Lu37-1-1 and Lu37-1-2). The genetic diversity among 1 913 cotton accessions, ...
网络释义 1. 非同义突变 ...同义突变(Synonymousmutation)、非同义突变(Nonsynonymous mutation)、无义突变(Nonsense mutation).Li等[1]的研究表明, …www.cnki.com.cn|基于1 个网页必应词典应用 准确权威无广告去官网了解更多 下载手机版必应词典 iOS Windows Phone Android 体验P C 版必应词典Win32 版Microsoft...
For synonymous SNPs, the codons after mutation in cancer-related genes are preferred and more frequently used in the genome compared to those in other genes. We also observed that the nonsynonymous or synonymous SNP sites in cancer-related genes are more conserved at DNA level. Interestingly, ...
Significantly, a viral variant with a single nonsynonymous nucleotide mutation on position 1069 of ZIKV open reading frame (G1069A), corresponding to an amino acid change (D67N) on the E protein, is sufficient to account for 100–1000-fold increase in its neurovirulence. These data provide ...
Among these, the G912D mutation had the least effect on apoB-48 secretion as compared with A31P. These results indicate that the hypobetalipoproteinemia phenotypes of the five kindreds, such as the reduced plasma cholesterol, TAG, and apoB concentrations (Table 1), are not caused solely by...
MutationAssessor predicts based on the evolutionary conservancy of affected residues and predicts the possible role of a mutation on phenotype using multiple sequence alignment80,81. Functional impact scores are generated from this evaluation of evolutionary information (FIS) and categorize nsSNP as ...
The Poly-Phen risk score indicates the Bayes posterior probability that a given mutation is damaging. Although PolyPhen risk score suggested a high probability to reduce protein stability or function,16 other prediction softwares showed the mild effect of the variants for which the score of SIFT ...
Under these simplifying assumptions, the expected number of synonymous polymorphisms (Ps) segregating within a collection ofnalleles iskLsNeu, whereNeis the effective population size,uis nucleotide mutation rate,Lsis the number of synonymous sites andkis a constant that depends upon several factors, incl...
A non-synonymous substitution is a nucleotide mutation that alters theamino acidsequence of a protein. When a non-synonymous substitution results in harmful biological change, the frequency of it can be low due to thenatural selection, usually <1%. On this occasion, a non-synonymous substituti...