The DNA is transcribed into RNA but the RNA does not specify oligo- or polypeptides; examples are the ribosomal rRNAs, transfer tRNAs, small nuclear snRNAs, small nucleolar snoRNAs, microRNAs, RNAi , as well as small RNA components of RNase P and other protein complexes. Actually, about ...
ciRNAs的形成依赖于侧翼RNA元件。侧翼RNA元件可能对内含子脱支成套非常重要。研究发现一些ciRNAs定位在细胞核中,可以与PolⅡ结合通过cis 作用模式调控宿主的转录活性。研究发现一类叫做EIciRNA的环状RNA与RNA PolⅡ关系密切。比如circEIF3J 和circPAIP2,定位在细胞核,与U1小核核糖核蛋白(snRNPs)结合,通过cis-ac...
长链非编码RNA(Long non-coding RNA, lncRNA)是长度大于 200 个核苷酸的非编码 RNA。lncRNA在剂量补偿效应(Dosage compensation effect)、表观遗传调控、细胞周期调控和细胞分化调控等众多生命活动中发挥重要作用,这体现出lncRNA的多功能性。由于这种多功能性,具体治疗方法需要根据lncRNA的不同功能作用机理进行调整。Ln...
Repertor:Xiaoning Yuan Oct.9.2012 Irnne.MP,Cheng G,Wieland.S,et al,2007 Noncoding RNA ? Introduction ? Classification ? Research method ? Mechanism ? The relationship with major disease 1.Introduction Noncoding RNA(ncRNA) is a kind of transcripts without the ability of coding proteins,which ...
In normal proliferating cells this RNA is mainly present in the nucleus. The promoter element was mapped between 437 to 346 nucleotides upstream of transcriptional start site and has both positive and negative regulatory elements. Deletion of the negative element converted the promoter to serum ...
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Over the past decade, substantial effort has been made towards the clinical application of RNA-based therapeutics, employing mostly antisense oligonucleotides and small interfering RNAs, with several gaining FDA approval. However, trial results have so far been ambivalent, with some studies reporting ...
NoncodingRNA非编码RNA-PPT精品文档 Repertor:XiaoningYuanOct.9.2019 Irnne.MP,ChengG,Wieland.S,etal，2019 NoncodingRNA Introduction ClassificationResearch methodMechanismTherelationshipwithmajordisease 1.Introduction NoncodingRNA(ncRNA)isakindoftranscriptswithouttheabilityofcodingproteins,which...
Noncoding RNAnoncoding RNA and ENCODE Pilot Projectconserved ncRNAs with limited distributionncRNAs from repeats and pseudogenesdoi:10.1002/9780470570418.ch14Alexander DonathSven FindeiβJana HertelManja MarzWolfgang OttoChristine SchulzPeter F. Stadler...
1、NoncodingRNA非编码RNA 1Repertor:Xiaoning Yuan Oct.9.2012Irnne.MP,Cheng G,Wieland.S,et al,2007NoncodingRNA非编码RNANoncoding RNAvIntroductionvClassification vResearch method vMechanism vThe relationship with major diseaseNoncodingRNA非编码RNA1.Introduction Noncoding RNA(ncRNA) is a kind of transc...