Non-coding RNA researchMaggie M,Balas,Aaron M,etc.Exploring the mechanisms behind long noncoding RNAs and cancer.[J].2018,3(3).Balas, M. M., and Johnson, A. M. (2018). Exploring the mechanisms behind long noncoding RNAs and cancer. Non Coding RNA Res. 3, 108-117. doi: 10.1016/...
This raises the possibility that a subset of cancer lncRNAs may also act as “driver-lncRNAs”, where SNVs promote cell fitness by altering lncRNA activity. However, recent studies have argued that mutations in NEAT1 and other lncRNAs arise from phenotypically neutral passenger effects2,33. To ...
The noncoding RNA LINP1 acts as a scaffold that links Ku and DNA-PKcs and enables efficient DNA double-strand-break repair through nonhomologous end joining (NHEJ), thereby enhancing the resistance of triple-negative breast cancer cells to radiation and
The development of biotechnology has led to the gradual discovery of many potential lncRNA functions. In this review, we discuss various lncRNAs that have been implicated in different human autoimmune diseases, focusing on their clinical applications as potential biomarkers and therapeutic targets in ...
MicroRNAs (miRNAs) are small RNA molecules of approximately 22 nucleotides that bind to the 3′-untranslated region (3′-UTR) of the target mRNA and negatively regulate the expression of the target gene at the transcriptional level [8]. miRNAs mainly participate in the pathogenesis of AML throug...
microRNA&NoncodingRNA microRNA 研究整体解决方案
A second putative 17-bp RNA-RNA hybrid of comparable predicted stability was identified that also overlaps with the same oligonucleotide-accessible region within EBER2 (site A versus site B of EBV type II; Figures S5B–S5D). Download: Download high-res image (729KB) Download: Download full-...
Mangeney M, Pothlichet J, Renard M et al (2005) Endogenous retrovirus expression is required for murine melanoma tumor growth in vivo. Cancer Res 65:2588–2591 ArticlePubMedCASGoogle Scholar Martignetti JA, Brosius J (1995) BC1 RNA: transcriptional analysis of a neural cell-specific RNA pol...
(Table2, Fig.2). miR-138 and miR-143 were found to regulate aerobic glycolysis in different types of tumor cells by directly targeting HK1 and HK2, respectively.58,59miR-155 and lncRNA urothelial cancer associated 1 (lncRNA UCA1) can increase HK2 expression by inhibiting miR-143 in ...
Therefore, we hypothesize that damage might induce the release of double stranded RNA (dsRNA) that activates TLR3 and its downstream pathways to induce RA synthesis and signaling to promote regeneration in its capacity as a known morphogen. Our objective was to test whether this occurs during WI...