The study of sample-matrix solution composition, pH and instrumental conditions allow the molecular weight determination of highly glycosylated proteins with a high percentage of sialic acid, e.g. erythropoietin. The glycosilation of this molecule which interferes with the production of multiply charged...
Although the potential ligands for E-selectin are numerous, it appears that for a molecule to have E-selectin binding activity it needs to be appropriately glycosylated. Indeed, only when the above-mentioned molecules are decorated with sialylated and fucosylated (sialofucosylated) oligosaccharides do...