The study of sample-matrix solution composition, pH and instrumental conditions allow the molecular weight determination of highly glycosylated proteins with a high percentage of sialic acid, e.g. erythropoietin. The glycosilation of this molecule which interferes with the production of multiply charged...
Good examples of heavily glycosylated tumor antigens are CEA and CEACAM1 (13, 14, 15, 16, 17, 18, 19), which can be secreted or expressed by colon cancer cells. Because the function of dendritic cells may be dependent on their binding properties as to self-antigens and pathogens, it ...
After uptake by various cells (human skin fibroblasts, rat neuroblastoma B 104, human neuroblastoma SHSY5Y, murine cerebellar cells), a radioactive and a fluorescent analog of a nondegradable glucosylceramide with sulfur in the glycosidic link were glycosylated to a cell-specific pattern of glycolipid...
- Glycosylated allergens- Lysosomal hydrolases, thyroglobulin, l-selectin, MUC-1, apoptotic cells CLRs are frequently promiscuous receptors that can bind more than one ligand. Myeloid CLRs can act as receptors for endogenous (self) or exogenous (non-self) ligands. Endogenous ligands can be further...
This new isoform corresponds to the first third of phosphacan, and although it is glycosylated, it is not a proteoglycan. It is not as readily extracted from brain tissue as phosphacan, perhaps because of stronger interactions with the cell surface. A recombinant protein corresponding to the ...