非编码RNA 1. Regulatory Roles of Noncoding RNA in Plant Development and Adaptabilities; 非编码RNA在植物发育与环境适应中的调控作用 2. Identified epigenetic processes involved in human disease include chromatin remodeling, genomic imprinting, X chromosome inactivation, and noncoding RNAs regulation. 在...
(D) GSEA using RNA-seq data from cells overexpressing PUM1 (upper) or PUM2 (lower) demonstrates significant downregulation of a custom geneset consisting of 331 genes that are downregulated in NORAD−/− cells at least 2-fold with an adjusted p value ≤ 0.01 (left) or upregulation of...
Therefore, these non-coding RNAs (ncRNAs) highlight the prominent role of RNA in the regulation of gene expression. Herein, we summarize recent research developments with the purpose of coming to a better understanding of non-coding RNAs and their mechanisms of action in cells, thus gaining a ...
The author reflects on a study on the function of non-coding RNA (ncRNA) transcripts in the regulation of microRNA (miRNA). He says that the effect of 3'untranslated region (3'UTR) on miRNAs activities is naturally occurring in the form of pseudogenes. He states that the regulation of ...
(b) Regulation of transcription: EIciRNA forms the EIciRNA-U1 snRNA complex through RNA-RNA interaction, and then binds to the promoter region of the parent gene with RNA polymerase II (RNA Pol. II), which is regulating its own expression. (c) Serves as an RNA binding protein (RBP) ...
Emerging evidence demonstrates the essential function of long non-coding RNAs (lncRNAs) in the regulation of β-cell function and the potential contribution of this type of RNA to the pathogenesis of diabetes7,8. Based on transcriptome profiling studies of islets and β-cell, more than 1000 isle...
《非编码RNA研究》(Non-coding Rna Research)是一本以Medicine-Biochemistry (medical)综合研究为特色的国际期刊。该刊由KeAi Communications Co出版商该刊已被国际重要权威数据库SCIE收录。期刊聚焦Medicine-Biochemistry (medical)领域的重点研究和前沿进展,及时刊载和报道该领域的研究成果,致力于成为该领域同行进行快速...
1b). Among 14 candidate lncRNAs, lncRNA-KRTAP5-AS1 presented the most obvious down-regulation in response to overexpression of miR-596. Simultaneously, expression of lncRNA-TUBB2A and lncRNA-KRTAP5-AS1 decreased the most following miR-3620-3p overexpression (Fig. 4a). To test the ...
Non-coding-RNA 李奇研发部经理基因芯片与生物信息领域从业9年 基因数量的矛盾 根据人类基因组序列预测，共3～4万个基因根据EST序列，获得10万个基因 大量垃圾序列存在的理由 CDS RegulaoryRNA hRNA RNA调控网络 RNA-RNARNA-DNARNA-蛋白质 蛋白间作用网络 代谢网络网络 DNA调控网络 DNA-蛋白质染色体修饰 其...
differentiation, and reprogramming of stem cells, imprinting,dosage compensationas well as a variety of human diseases[147]. In addition to this, lncRNA can also play a role in transcriptional gene silencing (TGS) as well as can modify epigenetic machinery thereby influencing the regulation of gen...