One of the major features described for noncoding RNAs is their ability to create tridimensional structures that serve as scaffold, guide, or decoy for proteins and other transcripts. Recent data support the notion of a prominent role of these interactions in the epigenetic modulation of gene ...
Non-Coding RNA Reagents for non-coding RNA functional analysis. Epigenetics & ncRNA Technical Resources Access useful technical application notes, webinars, and tutorials that explain new technologies and help you get up to speed with new methods. ...
2019,Computational Non-coding RNA Biology Chapter Hormones and Epigenetics 3.3Non-coding RNAs Non-coding sequences, once thought to be transcriptionally inert, have been shown to be actively transcribed into a large variety ofnon-coding RNAs. They are now the object of intensive research due to ...
RNAi and Non-coding RNA Research RNA interference (RNAi) is a very powerful tool for studying the basic biology of cells, allowing the knockdown of gene expression to study protein function in a wide range of cell types. Once viewed as a technique used only by select...
NON-coding RNAB cellsWNT signal transductionB cell lymphomaIntroduction: Enhancers are cell‐type specific regulatory DNA regions which play a key role in differentiation and development. Most active enhancers are transcribed in enhancer RNAs that can regulate transcription of relevant target genes by ...
Hirota K, Ohta K: Cascade transcription of mRNA-type long non-coding RNAs (mlonRNAs) and local chromatin remodeling. Epigenetics 2009, 4(1):5-7.Hirota K, Ohta K. Cascade transcription of mRNA-type long non-coding RNAs (mlonRNAs) and local chromatin remodeling. Epigenetics 2009; In press...
Although most of the non-coding RNA (ncRNA) species were initially dismissed as products of spurious transcription, a wide spectrum of ncRNA regulatory mechanisms is now emerging. ncRNA expression in the brain is dynamically regulated in an activity-dependent and spatiotemporally controlled manner, sug...
coding, intergenic DNA was later found to be a treasure of information that can be deciphered in the form of nucleotide elements (repetitive, transposable, interspersed elements etc) and different non-coding RNAs (rRNAs, tRNAs, regulatory RNAs etc). The RNA molecules lacking protein-coding...
et al. RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science 316, 1484–1488 (2007). Article CAS PubMed Google Scholar Rinn, J. L. et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129,...
Acute myeloid leukemia (AML) is the most common hematological malignancy in the world. Long noncoding RNAs (lncRNAs) play an important role in the development of physiology and pathology. Many reports have shown that lncRNA HOXA cluster antisense RNA 2 (