and the expression of noncoding RNAs)are considered to be contributing factors that affect bone homeostasis.Long noncoding RNAs(lncRNAs)were previously regarded as'transcriptional noise'with no biological functions.However,substantial evidence suggests that lncRNAs have roles in the epigenetic regulation of...
Heo, J. B., Lee, Y. S. & Sung, S. Epigenetic regulation by long noncoding RNAs in plants. Chromosome Res. 21, 685-693 (2013).Heo J B, Lee Y S, Sung S. 2013. Epigenetic regulation by long noncoding RNAs in plants. Chromosome Res, 21: 685-693....
long noncoding RNAmalignant hematological diseasesRecent discoveries demonstrate the importance of long noncoding RNA (lncRNA) in the regulation of multiple major processes impacting development, differentiation, and metastasis of hematological diseases through epigenetic mechanisms. In contrast to genetic ...
Noncoding RNA regulation. Different mechanisms of action of noncoding RNAs in epigenetic regulations. (1) <50 nt: MicroRNAs (miRNAs): miRNAs complement mRNAs and promote mRNA silencing or degradation. Small interfering RNAs(siRNA): silences gene expression. (2) 50–500 nt: nucleolar small ...
Long antisense non-coding RNAs and their role in transcription and oncogenesis. Cell Cycle 2010; 9: 2544–7.10.4161/cc.9.13.12145Search in Google Scholar PubMed PubMed Central 19. Hawkins PG, Morris KV. Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-...
Despite possessing limited protein-coding potential, long non-coding RNAs (lncRNAs) have been implicated in a myriad of pathologic conditions. Most well documented in cancer, one prominent intergenic lncRNA known as MALAT1 is notorious for its role in im
FIGURE 1. Expression of long noncoding RNAs during TGF-β-induced EMT of A549 and LC-2/ad lung cancer cells. A and B, QRT-PCR analysis was performed to detect the expression of various lncRNAs, which were reported to be implicated in ES cells or iPS cells, in A549 cells (A), and ...
The role of noncoding RNAs (ncRNAs) in epigenetic regulation of HSCs transdifferentiation into myofibroblasts has been established, providing new insights into gene expression changes during HSCs activation. NcRNAs play a crucial role in mediating the epigenetics of HSCs, serving as novel regulators in...
Epigenetic modifications and noncoding RNAs in cardiac hypertrophy and failure. Nat Rev Cardiol. 2015;12:488-97.Greco CM, Condorelli G. Epigenetic modifications and noncoding RNAs in cardiac hypertrophy and failure. Nat Rev Cardiol. 2015;12:488–97....
Finally, endogenously expressed noncoding RNAs, including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), play critical roles in the posttranscriptional regulation of gene expression by acting as competing RNAs, although they do not directly affect chromatin structure. lncRNAs are a large group...