Transcriptional regulationTranscription machineryEpigenetic regulationCancerMicroRNAs (miRNAs) are members of non-coding RNAs. They are involved in diverse biological functions. MiRNAs are precisely regulated in a tissue- and developmental-specific manner, but dysregulated in many human diseases, in particular...
Clinical response to adoptive T cell therapies is associated with the transcriptional and epigenetic state of the cell product. Thus, discovery of regulators of T cell gene networks and their corresponding phenotypes has potential to improve T cell thera
However, our understanding of how some of the critical metabolic enzymes are up/down-regulated, specifically through transcriptional regulation in ccRCC, remains incomplete. Moreover, it is unclear whether tumor subpopulations are metabolically distinct and in which pathways. VHL loss, the most frequent...
KIAA1199 is induced by inflammation and enhances malignant phenotype in pancreatic cancer We also examined the effect of inflammation on the transcriptional regulation of KIAA1199 using a pro-inflammatory cytokine and anti-inflammatory agent. ... S Kohi,N Sato,A Koga,... - 《Oncotarget》 被引...
日期:2017-08-23 标签:Transcriptional,and,Epigenetic,Regulation,of,KIF14,Overexpression,in,Ovarian,Cancer DNA甲基化研究案例(一) 一、调控通路 在正常细胞中,为了维持平衡,KIF14基因启动子的DNA是以甲基化状态存在;当细胞发生癌变时,转录因子SP1和YY1结合到KIF14基因启动子上促使DNA去甲基化从而促进KIF14的表达...
vertebrate neural progenitors are also temporally patterned by a combination of transcriptional and post-transcriptional mechanisms in response to extracellular signaling to regulate neural fate specification. In this review, we summarize recent advances in the study of temporal patterning of neural ...
the resulting model suggests novel mechanisms that underly the coordinated activation of several hundreds genes at a precise time point during embryonic development. background during the earliest stages of development, metazoan embryos undergo drastic morphological changes and transcriptional reprogramming. jus...
(1)thepromotersequencehasan unconventional structure, including dif f erent transcriptional regulation elements distributed throughout it, (2) GATA 4,GATA 6, and KLF5 are the key regulators of Claudin-9 expression, (3) Oct1, NF-κB, AP-1, c-Ets-1, and HNF-3β have the higherbinding af...
In this study, we mapped the transcriptional and epigenetic profiles of microglia from 3- to 24-month-old mice. We first discovered unexpected sex differences and identified age-dependent microglia (ADEM) genes during the aging process. We then compared the features of aging and reactivity in ...
Theoretical analysis predicts how the heterochromatic domain and LAD sizes depend on epigenetic and transcriptional regulation Next, we theoretically predict an explicit dependence of the sizes of interior heterochromatic domains and LADs on epigenetic and transcription reactions and the diffusion kinetics of...