Transcription Factors and EpigeneticsDaniel G. Tenen, MD
珠蛋白每个发育时期有开放gene和silicone gene表达也不一样,所以常作为转录组模型。 Transcription factors and co-factors又称反式转录原件。与之相对的是顺时转录原件,位于gene上游,是与调控gene在同一条染色体上的序列。在转录过程中会变化,富集后转录成环。 真核基因转录调控是远端promoter近端enhancer,同时转录因子...
Transcriptional dysregulation in Huntington's disease (HD) is an early event that shapes the brain transcriptome by both the depletion and ectopic activati... Valor,M Luis - 《Molecular Neurobiology》 被引量: 33发表: 2015年 Critical Link Between Epigenetics and Transcription Factors in the Induction...
(14).To establish whether poly(ADP-ribosyl)ation by itself is involved in the regulation of the promoter region of Dnmt1 gene or of another gene whose product is, in turn, involved in the regulation of Dnmt1 expression, we looked at transcription factors that undergo covalent poly(ADP-...
Mitosis is accompanied by dramatic changes in chromatin organization and nuclear architecture. Transcription halts globally and most sequence-specific transcription factors and co-factors are ejected from mitotic chromatin. How then does the cell maintai
In summary, we present a new computational toolkit, MAmotif, for detecting co-factors associated with the differential chromatin binding of proteins, based on quantitative comparison of their ChIP-seq data and systematic integration with TF binding information from motif analysis or other resources. Ap...
EpigeneticsBeltran AS, Blancafort P. Reactivation of MASPIN in non-small cell lung car- cinoma (NSCLC) cells by artificial transcription factors (ATFs). Epigenetics (2011) 6(2):224-35. doi:10.4161/epi.6.2.13700Beltran AS, Blancafort P (2011) Reactivation of MASPIN in non-small cell lung ...
Gene expression regulation requires precise transcriptional programs, led by transcription factors in combination with epigenetic events. Recent advances in epigenomic and transcriptomic techniques provided insight into different gene regulation mechanisms. However, to date, it remains challenging to understand ...
Cancer stemness is the main reason behind the heterogeneity in the tumor population, which provides for higher survival capability of the tumor and the increased ability to resist stress and therapies (chemotherapy as well as radiotherapy). There are many factors contributing to the acquisition of ...
WRKY transcription factors: Jack of many trades in plants . Plant Signal Behav 2014; 9 :e27700; PMID:24492469; http://dx.doi.org/10.4161/psb.27700 [ Cross Ref ]Bakshi M., Oelmüller R. WRKY transcription factors: Jack of many trades in plants. Plant Signaling and Behavior . 2014; 9 ...