by studying adult height variants and birth length, we demonstrate that genomic imprinting is not restricted to effectsin utero. Additionally, the unusual imprinting patterns observed in this study raise questions of what mechanism of imprinting at the molecular level can create opposite effects dependin...
Epigenetic Regulation of FKBP5 and a Potential Role in Mediating Gene–Stress Interactions An important mechanism that mediates lasting environ- mental effects on gene function occurs at the level of epigenetic regulation of gene transcription (Feil and Fraga, 2011; Telese et al, 2013). Epigenetic...
The liver plays a central role in the maintenance of homeostasis and health in general. However, there is substantial inter-individual variation in hepatic gene expression, and although numerous genetic factors have been identified, less is known about the epigenetic factors. Results By analyzing the...
B. (2016). Dynamics of epigenetic regulation at the single - cell level. 351(6274), doi:10.1126/science.aab2956.Bintu L, Yong J, Antebi YE, McCue K, Kazuki Y, Uno N, Oshimura M, Elowitz MB (2016) Dynamics of epigenetic regulation at the single-cell level. Science 351: 720 - ...
Assessment of plasma total tau level as a predictive biomarker for dementia and related endophenotypes. JAMA Neurol. 2019;76(5):598–606. Article PubMed PubMed Central Google Scholar Lea AJ, Vockley CM, Johnston RA, Del Carpio CA, Barreiro LB, Reddy TE, et al. Genome-wide quantification...
DNA methylation is an epigenetic mechanism that play an important role in gene regulation in response to environmental conditions. The understanding of DNA methylation at the whole genome level can provide insights into the regulatory me... R Garg,V Narayana Chevala,R Shankar,... - 《Scientific...
Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG Mol. Cell, 76 (2019), pp. 70-81.e9 Google Scholar 33 Y. Gao, G. Pei, D. Li, R. Li, Y. Shao, Q.C. Zhang, P. Li Multivalent m6A motifs promote phase separation of YTHDF proteins...
Epigenetic mechanisms are heritable traits that are mediated by changes in a genetic locus that do not involve a modification at the nucleotide level. As e... P Meyer - 《Current Opinion in Plant Biology》 被引量: 63发表: 2001年 Artificial gametes In vitro fertilization (IVF) has been an ...
42, 43 BS is a sodium bisulfite conversion method that provides quantitative DNA methylation level with single-base resolution. Sodium bisulfite treatment of genomic DNA converts unmethylated cytosine to uracil and then uracil become thymidine in subsequent PCR amplification and sequencing.44 5mC is ...
Epigenetic regulation of gene expression is a dynamic and reversible process that establishes normal cellular phenotypes but also contributes to human diseases. At the molecular level, epigenetic regulation involves hierarchical covalent modification of DNA and the proteins that package DNA, such as histone...