Tremendous progress achieved within the past two decades in understanding the biology of the nucleus and epigenetic mechanisms controlling gene expression allowed defining several levels in the regulation of cel
Finally, plant peculiarities for epigenetic control of gene regulation and future perspectives in this research area are discussed. This article is part of a Special Issue entitled: Epigenetic Control of cellular and developmental processes in plants. Research highlights ► Mechanisms modulating chromatin...
We also studied the regulatory landscape of IL2 (interleukin-2) in Jurkat T cells, primary T cells and chimeric antigen receptor (CAR) T cells and elucidated mechanisms of enhancer-mediated IL2 gene regulation. CRISPRai facilitates investigation of context-specific genetic interactions, provides new ...
The decline of brain function during aging is associated with epigenetic changes, including DNA methylation. Lifestyle interventions can improve brain function during aging, but their influence on age-related epigenetic changes is unknown. Using genome-w
22while the chromatin-modifying enzyme histone deacetylase 3 is required for the proliferation of TAPs23. Although there has been progress in identifying the gene regulatory networks in QNPs and TAPs, it is anticipated that additional transcriptional and epigenetic mechanisms work in concert to ...
Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), osteoporosis, gout, hyperthyroidism, hypothyroidism and others.
There has been remarkable progress in understanding melanoma pathogenesis in terms of genetic alterations. However, recent studies have revealed a complex involvement of epigenetic mechanisms in the regulation of gene expression, including methylation, chromatin modification and remodeling, and the diverse ...
For the involvement of possible epigenetic mechanisms, we refer to the difference in transposon density between the two species as the maize genome is more heavily bombarded by active repeats and we speculate that a more vigorous methylation tactic might be used in gene regulation in maize. Among...
In addition, in GC, the expression and action of AID is regulated by a series of epigenetic mechanisms. The suppression of Aicda in naïve B cells is due to DNA hypermethylation at the promoter region [107]. The H3 acetylation level of the Aicda gene locus in naïve B cells is low ...
gene 3 (LAG-3), T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) [25]. Although the number of newly discovered immune checkpoints is considerable, the ICIs approved by FDA remain limited due to the complexity of their mechanisms. Recently, an increasing number of studies in ...