Epigenetic mechanisms involved in the regulation of these genes were investigated by bisulfite sequencing and chromatin immunoprecipitation (ChIP) assays. We showed that low levels of MHC class-I molecules were associated with absent or reduced expression of the transporter associated with antigen ...
The decline of brain function during aging is associated with epigenetic changes, including DNA methylation. Lifestyle interventions can improve brain function during aging, but their influence on age-related epigenetic changes is unknown. Using genome-w
Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol. Cell 42, 451–464 (2011). Article CAS PubMed PubMed Central Google Scholar Jin, S.-G. et al. Tet3 reads 5-carboxylcytosine through its CXXC domain and is a potential ...
Before discussing epigenetic gene silencing in CSCs, the different classifications of stem cells and their properties will be introduced. This will be followed by an introduction to the different epigenetic mechanisms. Finally, there will be a discussion of the current knowledge of epigenetic ...
This review examines the known epigenetic mechanisms involved in regulation of astrocyte function, from development to neurodegeneration, and links these mechanisms to potential astrocyte-specific roles in neurodegenerative disease with a focus on potential opportunities for therapeutic intervention....
Out of these DEGs, eighteen are involved in epigenetic modifications or encode DNA methylation enzymes, such as DNA methylation-related gene DNMT3A (DNA methyltransferase 3A), MGMT (O-6-methylguanine-DNA methyltransferase) and etc. [2]. Galli et al. demonstrated that PolyI:C-mediated activation ...
Understanding the mechanistic effects of novel immunotherapy agents is critical to improving their successful clinical translation. These effects need to be studied in preclinical models that maintain the heterogenous tumor microenvironment (TME) and dys
Epigenetic Regulations and Promoter Characterization of CERIG (Cancer Endoplasmic Reticulum Gene-KIAA1199) Although human genome project is complete, the biological function of most genes remains obscure. In this thesis project, the regulatory mechanisms of a n... C Kuscu - Dissertations & Theses -...
The interplay between chromatin, transcription factors and genes generates complex regulatory circuits that can be represented as gene regulatory networks (GRNs). The study of GRNs is useful to understand how cellular identity is established, maintained and disrupted in disease. GRNs can be inferred...
For the involvement of possible epigenetic mechanisms, we refer to the difference in transposon density between the two species as the maize genome is more heavily bombarded by active repeats and we speculate that a more vigorous methylation tactic might be used in gene regulation in maize. Among...