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Long non-coding RNAs (lncRNAs) are diverse transcription products emanating from thousands of loci in mammalian genomes. Cis-acting lncRNAs, which constitute a substantial fraction of lncRNAs with an attributed function, regulate gene expression in a manner dependent on the location of their own sites...
In addition, unbiased analysis of global gene expression using RNA-seq revealed that loss of the APP family alters the transcription profile in the adult mouse cerebral cortex. These findings represent an initial step toward a more complete understanding of the role of APP family genes in the ...
Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases J. Periodontol., 79 (8 Suppl) (2008), pp. 1514-1519 Google Scholar [25] M. Mogi, et al. Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are ...
RNA-mediated epigenetic regulation of gene expression Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key regulators of gene expression, genome stability and defence against... D Holoch,D Moazed - 《Nature Reviews Genetics》 被引量: 382发表: 2015年 Genetic...
Within the last decade, OGT, OGA and O-GlcNAcylation have been shown to be at the nexus of epigenetic marks controlling gene expression during embryonic development, cell differentiation, in the maintenance of epigenetic states and in ... S Hardivillé,GW Hart - 《Current Opinion in Chemical Bi...
whichisconverte rompyruvateintumource s,iswi e yknownasanenergy sourcean metabo icby-pro uct.However,itsnon-metabo ic unctionsinphysio ogy an iseaseremainunknown.Hereweshowthat actate- erive acty ationo histone ysineresi uesservesasanepigeneticmo ifcationthat irect ystimu atesgene transcription ...
Transcriptional and epigenetic regulation of KIAA1199 gene expression in human breast cancer. PLoS One. 2012;7, e44661. 12. Evensen NA, Kuscu C, ... - 《Arthritis Research & Therapy》 被引量: 14发表: 2015年 加载更多来源期刊 Plos One 研究点推荐 KIAA1199 Gene Expression KIAA1199 引用...
Here we show that lactate-derived lactylation of histone lysine residues serves as an epigenetic modification that directly stimulates gene transcription from chromatin. We identify 28 lactylation sites on core histones in human and mouse cells. Hypoxia and bacterial challenges induce the production ...
The liver plays a central role in the maintenance of homeostasis and health in general. However, there is substantial inter-individual variation in hepatic gene expression, and although numerous genetic factors have been identified, less is known about the epigenetic factors. Results By analyzing the...