三、lncRNA(long non-coding RNA) IncRNA的长度一般大于200bp。根据基因组位点或相关的DNA特征,可以进一步进行分类(图4): 图4 长链非编码RNA的分类(e:增强子;exon:外显子) IncRNA 生物学意义: 1.作为信号分子行使功能:参与调控转录起始、延伸或终止等阶段。作为信号分子的IncRNA可用来标记时空、发育
et al. Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1. Genes Cells 16, 479–490 (2011). Article CAS PubMed PubMed Central Google Scholar Zhang, B. et al. A novel RNA motif mediates the strict nuclear ...
the CDS (light blue) and the 3′UTR (green). (Top, orange) mRNAs are primarily protein-coding RNA molecules: they carry a primary ORF (the CDS), and they may also present a short uORF in the 5′UTR. (Bottom, blue) non-canonical non-coding functions have been attributed to mRNAs. ...
现有的circRNA形成模型主要由以下几种: (1)“lariat-driven circularization”或者“exon skipping”; (2)“intron-pairing-driven circularization”或者“direct backsplicing”; (3)环状内含子RNA(ciRNAs)形成模式; (4)依赖于RBPs环化模式; (5)类似于可变剪切的可变环化模式...
An interesting regulatory capacity of other noncoding RNA is found from lncRNA (CCAT1), which acts as a miRNA sponge and a new type of lncRNA uses ultraconserved regions (UCRRNA, see below) of DNA sequences found in exon or intron regions.144 ...
cancer stem cells; non-coding RNAs; EMT; phenotypic and metabolic plasticity; anti-cancer therapies1. Introduction Malignant tumors are one of the most prevalent causes of death world-wide. According to Globocan (https://gco.iarc.fr/today/home (accessed on 16 December 2021)) in 2020, the ...
The latest advances in genome-wide techniques challenged the “protein-central dogma” with the discovery of the so-called non-coding RNAs (ncRNAs). Despite their lack of protein coding potential, ncRNAs have been largely demonstrated to regulate the majority of biological processes and have also ...
Tsuiji H, Yoshimoto R, Hasegawa Y, Furuno M, Yoshida M, Nakagawa S (2011) Competition between a noncoding exon and introns: gomafu contains tandem UACUAAC repeats and associates with splicing factor-1. Genes Cells: Devoted Mol Cell Mech 16(5):479–490 ...
46. Li Z, Huang C, Bao C, Chen L, Lin M, Wang X. et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 2015;22:256-64 47. Wu H, Yang L, Chen LL. The Diversity of Long Noncoding RNAs and Their Generation. Trends Genet. 2017;33:540...
(Fig.2a). Conversely, CCVs were depleted in the exons of protein-coding genes and enriched in the introns. In total, 119 mencRNA genes at 69/139 signals contained a CCV (417 in total; Additional file2: Tables S10 and S11) within a mencRNA exon. One example is the 2q14.2 risk ...