Assoc,Prof,IvanLambeve,mail,itlambevmail,bg,NONBETA,LACTAMANTIBIOTICS,MedicalUniversityofSofia,FacultyofMedicineDepartme
The invention provides a newly discovered oxadiazole class of antibiotics. The oxadiazoles impair cell-wall biosynthesis and exhibit activities against the Gram-positive bacteria such as the bacterium , including methicillin-resistant (MRSA) and vancomycin-resistant and linezolid-resistant . For example, ...
Binding of a non-beta-lactam- antibiotic to penicillin-binding proteins. Nature (London) 325:179-180.Nozaki Y , Katayama N , Ono H , Tsubotani S , Harada S , Okazaki H , et al. Binding of a non-beta-lactam antibiotic to penicillin-bind- ing proteins. J Antimicrob Chemother. 1991;...
Other than avoidance of the putative drug, management of hypersensitivity reactions to non beta-lactam antimicrobials may also include tolerance induction or desensitization [14] where no alternative antibiotics can be used and the benefits of reintroducing the drug outweigh the risks. Protocols have bee...
Ceftazidime/avibactam: a novel cephalosporin/nonbeta-lactam beta-lactamase inhibitor for the treatment of complicated urinary tract infections and complicated ... V Celeste,H Jose,A Nishaal - 《Drug Design Development & Therapy》 被引量: 9发表: 2016年 Ceftazidime–avibactam: novel antimicrobial combi...
Objective: Enterococcus faecalis and Enterococcus faecium are generally resistant to daptomycin and beta-lactam antibiotics. However, documented in vitro data suggests synergy between several beta-lactam antibiotics and daptomycin against resistant organisms. Primary goal of the study was to check various co...
The diagnosis of non-immediate type beta-lactam allergy was determined by provocation tests (n=11) prick/epidermal tests (n=3), patch tests (n=2). Only angioedema was found to increase the risk for diagnosis of non-immediate type beta-lactam allergy (OR:3.8, 95%CI:1.2-11.4, p=0.009)...
betalactamdrug allergyoral challenge testskin testingSuspected allergy to betalactam is common in children. However, the risk of anaphylaxis and fatal anaphylaxis is low, estimated at 0.015%004% and 0.0015002% of treated patients, respectively (1, 2). Up to recently, a provocation challenge was ...
On June 23, 2022, the U.S. Food and Drug Administration (FDA) notified the pharmaceutical industry of an important update to Non-Penicillin Beta-Lactam Drugs: A CGMP Framework for Preventing Cross-Contamination, published on April 17, 2013.1This new draft guidance broadens ...
Background: Extending the drug provocation test(DPT) period is recommended for patients with suspected nonimmediate beta-lactam antibiotic(BLA) allergy and negative DPT. There is no consensus regarding the duration of prolonged provocation. Objective: We aimed to determine the negative predictive value...