Nielsen N, Pascal V, Fasth AE et al. Balance between activating NKG2D, DNAM-1, NKP44 and NKP46 and inhibitory CD94/NKG2A receptors determine NK degranula- tion towards RA synovial fibroblasts. Immunology 2014; 142:581-93.NatasjaNielsen, VeroniquePascal, Andreas E. R.Fasth, Yvonne...
NK细胞的工作机制是,如果细胞表达的MHC-I类分子正常,KIR(抑制性杀伤细吧免疫球蛋白样受体)表达正常,NK细胞就不工作。相反,如果MHC-I 类分子下调,KIR表达降低,NK细胞就容易被激活,一些被激活的NK细胞受体,如NKG2D、NKp30、NKp46和NKp44,可以识别靶细胞上表达的应激诱导配体,从而为NK细胞杀伤靶细胞提供积极的信号,...
CTLA4Ig directly activates NK-92MI cells to induce marked expression of the NK cell effector molecules NKG2D and NKp44.doi:10.1371/JOURNAL.PONE.0083913.G006Peng YanmengLuo GaoxingZhou JunyiW. XiaojuanH. JieCui YanyanC. XianTan Jianglin