NK细胞的工作机制是,如果细胞表达的MHC-I类分子正常,KIR(抑制性杀伤细吧免疫球蛋白样受体)表达正常,NK细胞就不工作。相反,如果MHC-I 类分子下调,KIR表达降低,NK细胞就容易被激活,一些被激活的NK细胞受体,如NKG2D、NKp30、NKp46和NKp44,可以识别靶细胞上表达的应激诱导配体,从而为NK细胞杀伤靶细胞提供积极的信号,...
Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/ NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts. Immunology 2014; 142:581-93.Nielsen N, Pascal V, Fasth AE, et al. (2014). Balance between activating NKG2D, ...
百度试题 题目NK细胞表面能够识别结合MICA/B分子的杀伤活化受体是() A.NKG2DB.NKG2AC.NKG2CD.NKp46E.NKp44相关知识点: 试题来源: 解析 A
CTLA4Ig directly activates NK-92MI cells to induce marked expression of the NK cell effector molecules NKG2D and NKp44.doi:10.1371/JOURNAL.PONE.0083913.G006Peng YanmengLuo GaoxingZhou JunyiW. XiaojuanH. JieCui YanyanC. XianTan Jianglin