NKG2D-Fc for immunotherapyA composition comprising an NKG2D-Fc chimera and a pharmaceutically acceptable support wherein the NKG2D-Fc chimera binds an NKG2D ligand, for use for the treatment of a cancer expressing the NKG2D ligand.DRANOFF, GLENNVANNEMAN, MATTHEWFREEMAN, GORDON...
Examining the immune profile of mice treated with NKG2D-Fc reveals significant depletion of MDSCs and Tregs in the TME, as well as an increase in NK cells likely due to the reversed suppressive TME. In conclusion, NKG2D-Fc induces antitumor immunity and tumor control through the depletion of ...
生物活性(Activity):Immobilized human ULBP1-His (Cat:H1903-802H) at 10 μg/ml (100 μl/well) can bind human S4-Fc3L3-NKG2D, The EC50 of human S4-Fc3L3-NKG2D is 0.39-0.91 μg/ml. 表达区间(Protein Construction):A DNA sequence encoding the human NKG2D (NP_031386.2) (Phe78-Val216...
摘要: A composition comprising an NKG2D-Fc chimera and a pharmaceutically acceptable support wherein the NKG2D-Fc chimera binds an NKG2D ligand, for use for the treatment of a cancer expressing the NKG2D ligand.收藏 引用 批量引用 报错 分享 ...
Nkg2d-fc for immunotherapy 来自 掌桥科研 喜欢 0 阅读量: 20 申请(专利)号: US2009/006627 申请日期: 20091218 公开/公告号: WO2010080124A2 申请(专利权)人: 发明人: DRANOFF, Glenn,VANNEMAN, Matthew,FREEMAN, Gordon 国省代号: WO 被引量: 3 摘要: Methods for cancer immunotherapy are...
Characterization of NKG2D-Fc-IL2 protein.Tae, Heung Kang
NKG2D, Avi-Tag, Fc fusion 英文名称: NKG2D, Avi-Tag, Fc fusion 总访问: 106 国产/进口: 进口 半年访问: 12 产地/品牌: BPS 产品类别: 其他生物试剂 规格: 100 μg 最后更新: 2024-12-5 货号: 100252 CAS 号: 参考报价: 4480 立即询价 电话咨询 ...
在病毒感染或细胞癌变时,可因上述靶细胞表面MHCI类分子缺失或表达低下,即通过迷失自己"(missing-self)识别模式而使NK细胞表面杀伤抑制受体功能丧失;同时可因上述靶细胞异常或上调表达某些非MHCI类配体分子,即通过“诱导自己(inducedself)识别模式为NK细胞...
NKG2D-Fc-ADCC substantially enhanced NK reactivity also against HER2/neu-low targets that were unaffected by trastuzumab, as both compounds mediated their immunostimulatory effects in strict dependence of target Ag expression levels. Thus, in line with the hierarchically organized potential of the ...
Fc-optimized NKG2D-Fc constructs induce NK cell antibody-dependent cellular cytotoxicity against breast cancer cells independently of HER2/neu expression status. The ability of NK cells to mediate Ab-dependent cellular cytotoxicity (ADCC) largely contributes to the clinical success of antitumor Abs, ...