PDGF-DD与NKp44的结合会触发人类NK细胞中的ITAM信号传导: 作者探索了PDGF-DD-NKp44相互作用对NK细胞功能的影响: 随着浓度增加的PDGF-DD诱导的CD107a剂量依赖性细胞表面表达的增加,正常供体的IL-2活化的NKp44+ NK细胞被孵育(图S2B),这表明细胞因子的分泌和/或裂解颗粒的释放。 PDGF-DD通过NKp44而不是通过其他受...
最后检验PDGF-DD 作用于肿瘤细胞系 Because PDGF-DD/NKp44 interactions induced IFN-g and TNF-a secretion by NK cells, ILC3 and ILC1,we tested the hypothesis that this interaction might promote cell-cycle arrest in tumor cell lines. 这里使用了 Colo38 and Meljuso (both melanoma), OVCA (ovaria...
最后检验PDGF-DD 作用于肿瘤细胞系 Because PDGF-DD/NKp44 interactions induced IFN-g and TNF-a secretion by NK cells, ILC3 and ILC1,we tested the hypothesis that this interaction might promote cell-cycle arrest in tumor cell lines. 这里使用了 Colo38 and Meljuso (both melanoma), OVCA (ovaria...