53. C. Biron, K. Nguyen et al. “Natural killer cells in antiviral defense: function and regulation by innate cytokines..” Annual Review of Immunology(1999). 54. É. Vivier, D. Raulet et al. “Innate or Adaptive Immunity? The E...
[4]Gao, Y. et al. Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.Nat. Immunol. 18, 1004–1015 (2017). [5]Ghiringhelli, F., Menard, C., Martin, F. & Zitvogel, ...
Reference: Journal of Immunology. "Killer cell immunoglobulin-like receptors: function and signaling in natural killer cells." (Year and specific issue will depend on the latest research, but you can find the most relevant article in the journal's archive.)Reference: Nature Reviews Immunology. "T...
7. Myers, J.A. and J.S.Miller, Exploring the NK cell platformfor cancer immunotherapy. Nat Rev Clin Oncol, 2021. 18(2): p. 85-100. 8. Sarhan, D., et al., 161533 TriKE stimulates NK-cell function toovercome myeloid-derived supspanssor cells in MDS. Blood Adv, 2018. 2(12): p...
近期,国际期刊《Biochemistry and Biophysics Reports》中的一篇题为“Autologous NK cells propagated and activated ex vivo decrease senescence markers in human PBMCs”的研究论文,发现经扩增培养的自体NK细胞,除了表现出很强的杀肿瘤细胞和清除衰老细胞的能力,而且在回输后降低了血液中PBMC的衰老标记物。
参考资料: https://medicalxpress.com/news/2022-03-reveals-immune-natural-killer-cells.html 注:本文旨在介绍医学研究进展,不能作为治疗方案参考。如需获得健康指导,请至正规医院就诊。
蜕膜 NK 细胞的特征是 CD56bright CD16− KIR+ CD9+ CD49a+ 表型,细胞溶解性差,产生少量 IFN-γ,并且专门分泌细胞因子和趋化因子(VEGF、SDF-1、IP- 10) 促进新血管生成、组织重塑、免疫调节和胎盘形成(Vacca, P., Chiossone, L., Mingari, M. C. and Moretta, L., Heterogeneity of NK cells ...
国际期刊《Biochemistry and Biophysics Reports》中的一篇题为“Autologous NK cells propagated and activated ex vivo decrease senescence markers in human PBMCs”的研究论文,发现经扩增培养的自体NK细胞,除了表现出很强的杀肿瘤细胞和清除衰老细胞的能力,而且在输注后降低了血液中外周血单个核细胞(PBMC)的衰老标记...
11.Paul, S.; Lal, G. The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy. Front. Immunol. 2017, 8, 1124.12.Martin-Fontecha, A.; Thomsen, L.L.; Brett, S.; Gerard, C.; Lipp, M.; Lanzavecchia, A.; Sallusto, F. Induced recruitment of...
[1] Chiossone, Laura et al. “Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells.” Blood vol.[2] 李焱,叶敬伟,郭晓玲.IL-12、IL-15对急性髓系白血病患者骨髓来源CD34+白血病细胞转化...