Studies showed NK cell-based therapies have many advantages and promise for fighting metastatic cancers. We here review the function of the immune system in tumor progression, specifically focusing on the ability of NK cells in antimetastasis, how metastatic tumors escape the NK cell attack, as ...
RESEARCH HIGHLIGHTS Nature Reviews Immunology | AOP, published online 10 February 2012; doi:10.1038/nri3172 NATURAL KILLER CELLS Maturation and function of NK cells NK cell responsiveness may be therapeutically boosted by blocking NKp46 Natural killer (NK) cells are cytokine-producing cytotoxic innate ...
Cytokine-driven regulation of NK cell functions in tumor immunity: Role of the MICA-NKG2D system Natural killer (NK) cells are critical players during tumor growth control in immunocompetent hosts. These cells also establish a cross-talk with dendritic... NW Zwirner,MB Fuertes,MV Girart,... ...
Cell Death & Differentiation volume 29, pages 1901–1912 (2022)Cite this article 1468 Accesses 5 Citations 1 Altmetric Metrics details Abstract T helper 2 (Th2) cytokine production by invariant natural killer T (iNKT) cells is involved in the development of asthma, but the regulation of Th2...
- Apoptosis: An international journal on programmed cell death 被引量: 0发表: 2024年 The aryl hydrocarbon receptor maintains antitumor activity of liver resident natural killer cells after partial hepatectomy in C57BL/6J mice Background: Liver‐resident natural killer (lr‐NK) cells are distinct ...
Different doses of tumour inoculation in the peritoneal cavity did not suppress the cytotoxic function of NK cells from spleen suggesting that a direct interaction between NK cells and tumour cells is required for the suppression of NK cell cytotoxic function. Tumour inoculation induced secretion of ...
Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells The outcome of viral infections is dependent on the function of CD8+ T cells which are tightly regulated by costimulatory molecules. The NK cell receptor 2... V Schlaphoff,S Lunemann,PV Su...
6,8,14,15 Overall, these data suggest significant changes within the NK cell compartment in chronic viremic HIV-1 infection. However, little is known about the NK cell compartment during acute infection and the kinetics of these deregulations. Here, we report that distinct changes in the NK ...
aNK细胞是执行固有免疫和免疫监视作用的效应细胞,在生理条件下对自身正常组织细胞不产生杀伤作用。 The NK cell is carries out the inherent immunity and the immunity surveillance function effect cell, does not have the damaging effect under the physiological condition to own normal tissue cell. [translate...
Addition of antibodies to major histocompatibility complex class I (MHC class I) and F c gamma RIII (CD16) antigens resulted in the synergistic augmentation of natural killer (NK) cell death, and the loss of NK cell cytotoxic function. The binding of anti-CD16 and anti-class I antibodies...