Currently, there are three major modalities of autologous T cell immunotherapy: tumor-infiltrating lymphocyte (TIL) therapy, genetically engineered T cell receptors T (TCR-T) cell therapy, and CAR-T cell therapy [19]. TIL therapy, which involves expanding a heterogeneous population of endogenous T...
Currently, there are three major modalities of autologous T cell immunotherapy: tumor-infiltrating lymphocyte (TIL) therapy, genetically engineered T cell receptors T (TCR-T) cell therapy, and CAR-T cell therapy [19]. TIL therapy, which involves expanding a heterogeneous population of endogenous T...
wherein said pseudotyped retroviral vector particle or virus-like particle thereof comprises a modified baboon endogenous retrovirus (BaEV) envelope glycoprotein that is able of binding to and fusing with a hematopoietic cell membrane, thereby transferring biological material into said activated NK cells....
In recent decades, adoptive cell therapies have emerged as promising approaches for harnessing the endogenous cytotoxicity of immune cells and destroying malignant cells. Among immune cell candidates, natural killer (NK) cells have drawn significant attention due to their unique ability to recognize and ...
Potential effector molecules also make up the NKtb transcript list: SH2D1B interacting with SLAMF1 which could regulate signal transduction on endothelial cells (24) and oncogene product MYBL1 is a transcriptional activator that could alter NK-cell differentiation (25). Thus the differential ...
We also generated CAR T cells using a protocol based on CD3/CD28 costimulation, as this is more commonly used for clinical CAR T cell products [27, 28] (Fig. S3A). We observed similar transduction rates (Fig. S3B), but a higher fraction of CD4+ T cells (Fig. S3C) and relative ...
Moreover, considering the IL-15 efficacy in NK cell expansion and the capability of IL-21 in boosting NK cell antitumor cytotoxicity, a protocol based on the sequential use of these two cytokines has been developed (Wagner et al., 2017). Download: Download high-res image (552KB) Download:...
2024年3月28日,中山大学肿瘤防治中心蔡清清教授团队的免疫化疗成果“信迪利单抗(抗PD-1单抗)联合培门冬酶、吉西他滨和奥沙利铂(P-GEMOX)治疗晚期结外鼻型NK/T细胞淋巴瘤:一项多中心II期研究(SPIRIT)”(点击文末阅读原文查看)在线发表在Lance...
(iPSCs) and NK cell lines, have been used as sources to generate NK cells for immunotherapy. Moreover, genetic modification technologies to improve the proliferation of NK cells have also been developed to enhance the functions of NK cells. Here, we summarize the recent advances in expansion ...
cell lineages in these models, which are crucial for activating the adaptive immune response. In particular, the scarcity of human dendritic cells (DCs) as well as other myeloid lineages and NK cells, decreases the functionality of the engrafted HIS. The small frequencies of these cell ...