某些疾病如Chediak-Higashi或X性联淋巴增殖综合征患者，由于NK功能缺陷对恶性淋巴细胞增殖疾病特别易感。参与骨髓移植后移植物抗白血病效应（graft-versus-leukemia effect,GVL）:在体外NK细胞可杀伤某些淋巴样和髓样白血病细胞。骨髓移植后数周内，来自供体的NK细胞的PBL中占相当高的比例。此外，在体内NK细胞还可杀伤某...
69. G. Sconocchia, Michelle Lau et al. “The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target-cell interactions..” Blood (2005). 3666-72 . 70. C. Winter, J. Gumperz et ...
4. Bae, D.S. and J.K. Lee,Development of NK cell expansion methods using feeder cells from human myelogenous leukemia cell line.Blood Research, 2014.49(3): p. 154-161. 5. Ahn, Y.-O., et al.,Irradiated and activated autol...
三、基因编辑后的CAR-NK治疗白血病 2017年6月，MD Anderson癌症中心开展了一项脐带血来源的嵌合抗原受体NK细胞（CAR-NK）临床研究，并首次进入人体试验1/2期阶段。这些CAR-NK细胞被用于治疗复发或耐药性慢性淋巴细胞性白血病，急性淋巴细胞性白血病或非霍奇金淋巴瘤，这一成果发表在知名学术期刊《Leukemia》上。四、中...
Aggressive NK cell leukemia (ANKL) is a rare malignant lymphoproliferative disorder of mature NK cells closely associated with Epstein-Barr virus (EBV) and more common in East Asia than in other areas. Significant variations exist in the morphology of ANKL tumor cells, from typical large granular...
NK细胞是第三类淋巴细胞,其表面缺少T细胞和B细胞的特异性标志如TCR和SmIg,曾称为裸细胞(null cell)。这类细胞不依赖于抗原刺激,能自发地溶解多种肿瘤细胞和被病毒感染细胞,称为自然杀伤细胞,主要存在于外周血和脾脏中,在人外周血中占淋巴细胞的5%～10%。 认识NK细胞 70 年代初 NIC 的研究人员在研究 T ...
[1]Shunya Ikeda et al. CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant. Nature Cancer(2025) https://www.nature.com/articles/s43018-025-00934-1 [2]https://www.nature.com/articles/s43018-025-00913-6 ...
[2] Gong, J. H., Maki, G., & Klingemann, H. G. (1994). Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells. Leukemia, 8(4), 652–658. [3] Arai, S., Meagher, R., & Klingemann, H. (2008). Infusion...
随着对NK细胞和Venetoclax的进一步研究，我们期待未来能够开发出更有效的治疗方法，以改善癌症患者的生活质量和生存率。这一发现再次证明了科学研究在推动医学进步中不可或缺的作用。参考 Wang, Yan et al. “Venetoclax acts as an immunometabolic modulator to potentiate adoptive NK cell immunotherapy against leukemi...
Nk CellRibosome-LAMELLA ComplexA 36-year-old male was admitted to the hospital with anemia and leukopenia. A bone marrow specimen revealed the proliferation of leukemic cells with flower-like nuclei observed in adult T-cell leukemia. The leukemic cells were positive for HLA-DR, CD2, CD7, and...