•疲乏、发热、盗汗、体重减轻(约30%的患者)•慢性中性粒细胞减少导致的复发性感染•风湿性关节炎,约40%的病例存在自身抗体•10-30%患者存在轻度贫血,<25%患者存在血小板减少•约25%的患者存在脾肿大 参考文献:Schreiber J, Pichler A, Kornauth C, et al. T-...
成熟(或外周)T细胞和自然杀伤(natural killer,NK)细胞白血病包括T幼淋巴细胞白血病(T-prolymphocytic leukemia,T-PLL),T大颗粒淋巴细胞白血病(T-cell large granular lymphocytic leukemia,T-LGLL),NK细胞慢性淋巴增殖性疾病(chronic lymphoproliferative disorder...
NK cell, L-asparaginase, JAK/STAT, allogeneic hematopoietic cell transplantation, Epstein-Barr virus, LGLAggressive NK cell leukemia (ANKL) is a rare malignant lymphoproliferative disorder of mature NK cells closely associated with Epstein-Barr virus (EBV) and more common in East Asia than in ...
•疲乏、发热、盗汗、体重减轻(约30%的患者)•慢性中性粒细胞减少导致的复发性感染•风湿性关节炎,约40%的病例存在自身抗体•10-30%患者存在轻度贫血,<25%患者存在血小板减少•约25%的患者存在脾肿大 参考文献:Schreiber J, Pichler A, Kornauth C, et al. T-Cell Large Granular Lymphocyte Leukemia: ...
NK细胞显著的形态为大颗粒细胞(LGL),占淋巴样细胞的1/3。2001年正式将NK细胞白血病列为T/NK细胞肿瘤中的一个独特临床亚型。侵袭性NK细胞白血病是一类非常罕见的大颗粒淋巴细胞白血病(LGLL),LGLL包括T细胞型LGLL(T-LGLL)和NK细胞型LGLL(即ANKL)。2008年WHO在淋巴组织肿瘤分类中将其独立列为ANKL,与淋巴结外NK/T细胞...
Cell子刊:iPSC来源的NK细胞经过基因编辑后显示出更强大的抗肿瘤活性丨医麦猛爆料 医麦客 中国生物医药产业新媒体|公众号【eMedClub】 近日,加大圣地亚哥分校(UCSD)和挪威奥斯陆大学医院的一个研究团队,开发了一种基因编辑的“现货”NK细胞疗法,临床前研究数据表明对急性髓系白血病(Acute myeloid leukemia,AML… ...
"ANKL patients often had mutations in the STAT3 and DDX3X genes which points towards partly shared genetic background with other NK- and T-cell malignancies," says Professor Satu Mustjoki, University of Helsinki, whose group initially discovered somatic STAT3 mutations in LGL leukemia. ...
NK大颗粒淋巴细胞白血病NK- large granular lymphocytic leukemia(NK-LGL) 成人T细胞白血病/淋巴瘤 Adult T-cell leukemia/lymphoma (ATLL) Sézary综合征Sezary syndrome (SS) 侵袭性NK细胞白血病 Aggressive NK-cell leukemia 原发性皮肤T细胞淋巴瘤Primary cutaneous T- cell lymphomas ...
一、什么是NK细胞?自然杀伤细胞(Natural killer cell,NK细胞 ),是除 T细胞、B细胞之外的第三大类淋巴细胞,不表达T细胞和B细胞所特有的膜表面分子。无需抗原的预先刺激与活化即可… 阅读全文 什么是细胞免疫治疗 为什么要做细胞免疫治疗 细胞科普 2015年,“魏则西事件”后,我国全面整顿叫停了细胞治疗的临床应用。
Leukemia of NK cells [2] was first identified as a CD3− subtype of large granular lymphocyte (LGL) leukemia, NK-LGL leukemia [3]. Meanwhile, angiocentric immunoproliferative lesions, first described as a subset of T-cell lymphoma [4], were found to express NK cell antigens [5], [6...