We demonstrate for the first time that TRAIL messenger RNA (mRNA) and protein expression levels are elevated in LGL leukemia patient cells, and soluble TRAIL is elevated in patient sera. We also show that TRAIL contributes to survival of both T- and NK-LGLs. We identify DcR2 as the ...
Clonal CD8+/T-cell receptor (TCR)αβ+T-cell large granular lymphocyte (T-LGL) proliferations constitute the most common subtype of T-LGL leukemia. Although the etiology of T-LGL leukemia is largely unknown, it has been hypothesized that chronic antigenic stimulation contributes to the pathogenes...
Researchers of the University of Helsinki, Helsinki University Central Hospital and Institute for Molecular Medicine Finland, have discovered that a mutation in the STAT3 gene is an underlying cause for LGL leukemia. Since the STAT3 gene is also abnormally expressed in many other cancers and ...