在许多例子中,NF-κB二聚体通过和特异DNA结合位点结合激活目标基因,这需要其他转录因子的辅助,包括信号传导子和转录激活子(STAT)还有激活蛋白1(AP1)家族成员以及干扰素调节因子(IRFs)。NF-κB主要的信号靶点基因包括编码促炎症因子(如TNF、IL-1、IL-6)、生长因子(如粒-巨...
Real-time transcription-polymerase chain reaction (RT-PCR) analysis was used to evaluate the expression of TNFAIP3, NF-kB and SMAD mRNA in MSC cells. Vectors carrying either IkB/IKK尾-specific shRNA, A20 cDNA/TNFAIP3-specific shRNA or SMAD7-specific shRNA were transduced into the MSCs from...
且这些基因主要富集在NF-κB信号通路中,LPS处理使NOD1、RIPK2、NFKBIA、NFKBIB和TNFAIP3 mRNA中的m6A修饰显著变化。此外,METTL3敲除或FTO过表达都使NOD1/NF-κB通路中的基因水平发生变化,表明该通路的激活受m6A RNA甲基化调控,且m6A RNA甲基化水平变化可能与活性氧(ROS)、HIF-1α和MAT2A增加有关。总之,LPS通过改变...
(TRIF), TNFAIP3, TRADD, TRAF2, TRAF3, TRAF6. Cytoplasmic Sequestering/Releasing of NFκB: BCL3, CHUK (IKKa), IKBKB, IKBKG, NFKBIA, NFKBIE. Transcription Factors: NFKB1, NFKB2, REL, RELA, RELB. NFκB Responsive Genes: Immune Response: CCL2 (MCP-1), CCL5 (RANTES), CSF1 (MCSF)...
Overall, we identified TRAF3 and TNFAIP3inactivation in 5.3% and 2.4%, respectively. To our knowledge,this is the first study showing the inactivation of bona fidetumor suppressor genes in WM patients. Furthermore, these genesare negative regulators of NF-kB signaling pathway, highlightingits ...
Ligands and Receptors: IL1R1, RAF1, TLR7, TLR9. Kinases: AKT1, RAF1. Transcription Factors: ATF1, EGR1, ELK1, FOS, JUN, TNFAIP3. Inflammatory Response: CCL2 (MCP-1), FOS, IL1A, IL1R1, TLR7, TLR9. 在线留言 姓名 电话号码 电子邮箱 公司名称 地址 留言* 提交...
pro-005 重组人TNFAIP3相互作用蛋白1 1µg $50 + pro-006 重组人包含SH2结构域的1A 5µg $50 + pro-007 重组人p53和DNA损伤调节1 5µg $50 + pro-008 重组人细胞分化1所需的RCD11 5µg $50 + pro-009 重组人Kv通道相互作用蛋白3 5µg $50 + pro-010 重组人吩嗪类生物合成蛋白结构...
Located in the cytoplasm, A20 is a zinc finger protein encoded by TNFAIP3 that regulates the NF-kB pathway via triggering IKKg destruction9. TNIP1, NFKBIA and TRAF3IP2 encoding the NF-kB regulatory proteins ABIN, IkBa and ACT1, respectively, were reported to be associated with psoriasis10...
In addition, genes involved in regulation of proteasome functions, such as USP34, WSB1, BRE and the NFkB regulator TNFAIP3/A20 (refs 4,6) are among the IBD susceptibility candidates. In the past several decades, advances in the understanding of the molecular pathogenesis in IBD have been ...
Transcription Factors: ATF1, EGR1, ELK1, FOS, JUN, TNFAIP3.Inflammatory Response: CCL2 (MCP-1), FOS, IL1A, IL1R1, TLR7, TLR9. NFkB信号通路ChIP PCR芯片 NFkB Signaling Pathway ChIP PCR Array由上海英拜生物科技有限公司为您提供,如您想了解更多关于NFkB信号通路ChIP PCR芯片 NFkB Signaling ...